An N-terminal antibody promotes the transformation of amyloid fibrils into oligomers and enhances the neurotoxicity of amyloid-beta: the dust-raising effect

BACKGROUND: Senile plaques consisting of amyloid-beta (Aβ) are the major pathological hallmark of Alzheimer’s disease (AD) and have been the primary therapeutic target. Immunotherapies, which are designed to remove brain Aβ deposits, increased levels of soluble Aβ and accelerated brain atrophy in so...

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Detalles Bibliográficos
Autores principales: Liu, Yu-Hui, Bu, Xian-Le, Liang, Chun-Rong, Wang, Ye-Ran, Zhang, Tao, Jiao, Shu-Sheng, Zeng, Fan, Yao, Xiu-Qing, Zhou, Hua-Dong, Deng, Juan, Wang, Yan-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551765/
https://www.ncbi.nlm.nih.gov/pubmed/26311039
http://dx.doi.org/10.1186/s12974-015-0379-4

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