Novel Small Molecule Agonist of TGR5 Possesses Anti-Diabetic Effects but Causes Gallbladder Filling in Mice

Activation of TGR5 via bile acids or bile acid analogs leads to the release of glucagon-like peptide-1 (GLP-1) from intestine, increases energy expenditure in brown adipose tissue, and increases gallbladder filling with bile. Here, we present compound 18, a non-bile acid agonist of TGR5 that demonst...

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Detalles Bibliográficos
Autores principales: Briere, Daniel A., Ruan, Xiaoping, Cheng, Christine C., Siesky, Angela M., Fitch, Thomas E., Dominguez, Carmen, Sanfeliciano, Sonia Gutierrez, Montero, Carlos, Suen, Chen S., Xu, Yanping, Coskun, Tamer, Michael, M. Dodson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551797/
https://www.ncbi.nlm.nih.gov/pubmed/26312995
http://dx.doi.org/10.1371/journal.pone.0136873

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