miR-378b Promotes Differentiation of Keratinocytes through NKX3.1

MicroRNA (miRNA) is a kind of short non-coding RNA, involved in various cellular processes. During keratinocyte differentiation, miRNAs act as important regulators. In this study, we demonstrated by microarray assay that the expression of miR-378b significantly increased during keratinocytes differe...

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Detalles Bibliográficos
Autores principales: Wang, Xi-liang, Zhang, Tao, Wang, Jing, Zhang, Dian-bao, Zhao, Feng, Lin, Xue-wen, Wang, Zhe, Shi, Ping, Pang, Xi-ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551849/
https://www.ncbi.nlm.nih.gov/pubmed/26313654
http://dx.doi.org/10.1371/journal.pone.0136049
Descripción
Sumario:MicroRNA (miRNA) is a kind of short non-coding RNA, involved in various cellular processes. During keratinocyte differentiation, miRNAs act as important regulators. In this study, we demonstrated by microarray assay that the expression of miR-378b significantly increased during keratinocytes differentiation. Our findings showed that miR-378b could inhibit proliferation, migration and differentiation in keratinocytes. Luciferase reporter assays showed that miR-378b directly target NKX3.1. Silencing of NKX3.1 could coincide with the effects of miR-24 overexpression. In conclusion, our results demonstrate miR-378b promote keratinocytes differentiation by targeting NKX3.1. Manipulation of miR-378b may afford a new strategy to clinic treatment of skin injury and repair.

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