Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

Proteasomes are central regulators of protein homeostasis in eukaryotes. Proteasome function is vulnerable to environmental insults, cellular protein imbalance and targeted pharmaceuticals. Yet, mechanisms that cells deploy to counteract inhibition of this central regulator are little understood. To...

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Detalles Bibliográficos
Autores principales: Tsvetkov, Peter, Mendillo, Marc L, Zhao, Jinghui, Carette, Jan E, Merrill, Parker H, Cikes, Domagoj, Varadarajan, Malini, van Diemen, Ferdy R, Penninger, Josef M, Goldberg, Alfred L, Brummelkamp, Thijn R, Santagata, Sandro, Lindquist, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551903/
https://www.ncbi.nlm.nih.gov/pubmed/26327695
http://dx.doi.org/10.7554/eLife.08467

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