Haploinsufficiency predictions without study bias

Any given human individual carries multiple genetic variants that disrupt protein-coding genes, through structural variation, as well as nucleotide variants and indels. Predicting the phenotypic consequences of a gene disruption remains a significant challenge. Current approaches employ information...

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Detalles Bibliográficos
Autores principales: Steinberg, Julia, Honti, Frantisek, Meader, Stephen, Webber, Caleb
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551909/
https://www.ncbi.nlm.nih.gov/pubmed/26001969
http://dx.doi.org/10.1093/nar/gkv474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551909/
https://www.ncbi.nlm.nih.gov/pubmed/26001969
http://dx.doi.org/10.1093/nar/gkv474

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