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Integrative genomic analysis in K562 chronic myelogenous leukemia cells reveals that proximal NCOR1 binding positively regulates genes that govern erythroid differentiation and Imatinib sensitivity

To define the functions of NCOR1 we developed an integrative analysis that combined ENCODE and NCI-60 data, followed by in vitro validation. NCOR1 and H3K9me3 ChIP-Seq, FAIRE-seq and DNA CpG methylation interactions were related to gene expression using bootstrapping approaches. Most NCOR1 combinati...

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Detalles Bibliográficos
Autores principales:	Long, Mark D., van den Berg, Patrick R., Russell, James L., Singh, Prashant K., Battaglia, Sebastiano, Campbell, Moray J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551916/ https://www.ncbi.nlm.nih.gov/pubmed/26117541 http://dx.doi.org/10.1093/nar/gkv642

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