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Importin-β facilitates nuclear import of human GW proteins and balances cytoplasmic gene silencing protein levels

MicroRNAs (miRNAs) guide Argonaute (Ago) proteins to distinct target mRNAs leading to translational repression and mRNA decay. Ago proteins interact with a member of the GW protein family, referred to as TNRC6A-C in mammals, which coordinate downstream gene-silencing processes. The cytoplasmic funct...

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Detalles Bibliográficos
Autores principales:	Schraivogel, Daniel, Schindler, Susann G., Danner, Johannes, Kremmer, Elisabeth, Pfaff, Janina, Hannus, Stefan, Depping, Reinhard, Meister, Gunter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551936/ https://www.ncbi.nlm.nih.gov/pubmed/26170235 http://dx.doi.org/10.1093/nar/gkv705

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