ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expression

The reduced expression levels and functional impairment of global miRNAs are related to various human diseases, including cancers. However, relatively little is known about how global miRNA function may be upregulated. Here, we report that global miRNA function can be enhanced by Rho-associated, coi...

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Detalles Bibliográficos
Autores principales: Yoshikawa, Takeshi, Wu, Jianfeng, Otsuka, Motoyuki, Kishikawa, Takahiro, Ohno, Motoko, Shibata, Chikako, Takata, Akemi, Han, Felicia, Kang, Young Jun, Chen, Chyi-Ying A., Shyu, Ann-Bin, Han, Jiahuai, Koike, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551943/
https://www.ncbi.nlm.nih.gov/pubmed/26187994
http://dx.doi.org/10.1093/nar/gkv728

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