Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis

To support growth, tumour cells reprogramme their metabolism to simultaneously upregulate macromolecular biosynthesis while maintaining energy production. Uncoupling proteins (UCPs) oppose this phenotype by inducing futile mitochondrial respiration that is uncoupled from ATP synthesis, resulting in...

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Detalles Bibliográficos
Autores principales: Nowinski, Sara M., Solmonson, Ashley, Rundhaug, Joyce E., Rho, Okkyung, Cho, Jiyoon, Lago, Cory U., Riley, Christopher L., Lee, Sunhee, Kohno, Shohei, Dao, Christine K., Nikawa, Takeshi, Bratton, Shawn B., Wright, Casey W., Fischer, Susan M., DiGiovanni, John, Mills, Edward M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552083/
https://www.ncbi.nlm.nih.gov/pubmed/26310111
http://dx.doi.org/10.1038/ncomms9137

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