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Polyurethane membrane with porous surface for controlled drug release in drug eluting stent

BACKGROUND: Membrane covered drug eluting stents (DES) were prepared to prevent tumor ingrowth and to control drug release. Polyurethane (PU) is commonly used for DES coating material because of high tensile strength. The release of paclitaxel (PTX) may increase from porous PU membrane. RESULTS: Pol...

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Detalles Bibliográficos
Autores principales: Seo, Eun Ha, Na, Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552100/
https://www.ncbi.nlm.nih.gov/pubmed/26331066
http://dx.doi.org/10.1186/2055-7124-18-15
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author Seo, Eun Ha
Na, Kun
author_facet Seo, Eun Ha
Na, Kun
author_sort Seo, Eun Ha
collection PubMed
description BACKGROUND: Membrane covered drug eluting stents (DES) were prepared to prevent tumor ingrowth and to control drug release. Polyurethane (PU) is commonly used for DES coating material because of high tensile strength. The release of paclitaxel (PTX) may increase from porous PU membrane. RESULTS: Polyethylene glycol (PEG) was incorporated into PU membranes to form porous structure and control the release of hydrophobic anti-cancer drug such as PTX. The bare metal stents were coated with PEG incorporated PU and then, PEG was washed out to form porous structure. The crystallization of PTX was inhibited in porous PU membranes and the release of PTX from porous PU membranes was approximately 8.6% more extended over 19 days. CONCLUSIONS: The enhanced release of PTX from porous PU membranes may increase the patency for the DES covering materials.
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spelling pubmed-45521002015-09-01 Polyurethane membrane with porous surface for controlled drug release in drug eluting stent Seo, Eun Ha Na, Kun Biomater Res Research Article BACKGROUND: Membrane covered drug eluting stents (DES) were prepared to prevent tumor ingrowth and to control drug release. Polyurethane (PU) is commonly used for DES coating material because of high tensile strength. The release of paclitaxel (PTX) may increase from porous PU membrane. RESULTS: Polyethylene glycol (PEG) was incorporated into PU membranes to form porous structure and control the release of hydrophobic anti-cancer drug such as PTX. The bare metal stents were coated with PEG incorporated PU and then, PEG was washed out to form porous structure. The crystallization of PTX was inhibited in porous PU membranes and the release of PTX from porous PU membranes was approximately 8.6% more extended over 19 days. CONCLUSIONS: The enhanced release of PTX from porous PU membranes may increase the patency for the DES covering materials. BioMed Central 2014-10-08 /pmc/articles/PMC4552100/ /pubmed/26331066 http://dx.doi.org/10.1186/2055-7124-18-15 Text en © Seo and Na; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Seo, Eun Ha
Na, Kun
Polyurethane membrane with porous surface for controlled drug release in drug eluting stent
title Polyurethane membrane with porous surface for controlled drug release in drug eluting stent
title_full Polyurethane membrane with porous surface for controlled drug release in drug eluting stent
title_fullStr Polyurethane membrane with porous surface for controlled drug release in drug eluting stent
title_full_unstemmed Polyurethane membrane with porous surface for controlled drug release in drug eluting stent
title_short Polyurethane membrane with porous surface for controlled drug release in drug eluting stent
title_sort polyurethane membrane with porous surface for controlled drug release in drug eluting stent
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552100/
https://www.ncbi.nlm.nih.gov/pubmed/26331066
http://dx.doi.org/10.1186/2055-7124-18-15
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