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Down-regulation of TORC2-Ypk1 signaling promotes MAPK-independent survival under hyperosmotic stress

In eukaryotes, exposure to hypertonic conditions activates a MAPK (Hog1 in Saccharomyces cerevisiae and ortholog p38 in human cells). In yeast, intracellular glycerol accumulates to counterbalance the high external osmolarity. To prevent glycerol efflux, Hog1 action impedes the function of the aquag...

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Detalles Bibliográficos
Autores principales:	Muir, Alexander, Roelants, Françoise M, Timmons, Garrett, Leskoske, Kristin L, Thorner, Jeremy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552222/ https://www.ncbi.nlm.nih.gov/pubmed/26274562 http://dx.doi.org/10.7554/eLife.09336

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