Development of APE1 enzymatic DNA repair assays: low APE1 activity is associated with increase lung cancer risk

The key role of DNA repair in removing DNA damage and minimizing mutations makes it an attractive target for cancer risk assessment and prevention. Here we describe the development of a robust assay for apurinic/apyrimidinic (AP) endonuclease 1 (APE1; APEX1), an essential enzyme involved in the repa...

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Detalles Bibliográficos
Autores principales: Sevilya, Ziv, Leitner-Dagan, Yael, Pinchev, Mila, Kremer, Ran, Elinger, Dalia, Lejbkowicz, Flavio, Rennert, Hedy S., Freedman, Laurence S., Rennert, Gad, Paz-Elizur, Tamar, Livneh, Zvi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Original Manuscript
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552243/
https://www.ncbi.nlm.nih.gov/pubmed/26045303
http://dx.doi.org/10.1093/carcin/bgv082

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