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Effect of porous polycaprolactone beads on bone regeneration: preliminary in vitro and in vivo studies
BACKGROUND: For the effective bone regeneration with appropriate pathological/physiological properties, a variety of bone fillers have been adapted as a therapeutic treatment. However, the development of ideal bone fillers is still remained as a big challenge in clinical practice. The main aims of t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552305/ https://www.ncbi.nlm.nih.gov/pubmed/26331069 http://dx.doi.org/10.1186/2055-7124-18-18 |
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author | Byun, June-Ho Lee, Han A Reum Kim, Tae Ho Lee, Jin Ho Oh, Se Heang |
author_facet | Byun, June-Ho Lee, Han A Reum Kim, Tae Ho Lee, Jin Ho Oh, Se Heang |
author_sort | Byun, June-Ho |
collection | PubMed |
description | BACKGROUND: For the effective bone regeneration with appropriate pathological/physiological properties, a variety of bone fillers have been adapted as a therapeutic treatment. However, the development of ideal bone fillers is still remained as a big challenge in clinical practice. The main aims of this study are i) fabrication of a highly porous PCL beads; and ii) the estimation of the potential use of the porous PCL beads as a bone filler through preliminary animal study. RESULTS: The porous PCL beads with size range of 53 ~ 600 μm (425 ~ 500 μm dominantly) are fabricated by a spray/precipitation method using a double nozzle spray and PCL solution (in tetraglycol). The PCL beads show highly porous inner pore structure and the pores are interconnected with outer surface pores. For the preliminary animal study, we recognize that the porous PCL bead can induce the new bone formation from the outer surface of bone defect toward the bone marrow cavity through the bead matrix. CONCLUSIONS: From the preliminary results, we can suggest that the highly porous PCL beads may be a promising candidate as a bone filler (scaffolding matrix) for the effective bone regeneration. |
format | Online Article Text |
id | pubmed-4552305 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45523052015-09-01 Effect of porous polycaprolactone beads on bone regeneration: preliminary in vitro and in vivo studies Byun, June-Ho Lee, Han A Reum Kim, Tae Ho Lee, Jin Ho Oh, Se Heang Biomater Res Research Article BACKGROUND: For the effective bone regeneration with appropriate pathological/physiological properties, a variety of bone fillers have been adapted as a therapeutic treatment. However, the development of ideal bone fillers is still remained as a big challenge in clinical practice. The main aims of this study are i) fabrication of a highly porous PCL beads; and ii) the estimation of the potential use of the porous PCL beads as a bone filler through preliminary animal study. RESULTS: The porous PCL beads with size range of 53 ~ 600 μm (425 ~ 500 μm dominantly) are fabricated by a spray/precipitation method using a double nozzle spray and PCL solution (in tetraglycol). The PCL beads show highly porous inner pore structure and the pores are interconnected with outer surface pores. For the preliminary animal study, we recognize that the porous PCL bead can induce the new bone formation from the outer surface of bone defect toward the bone marrow cavity through the bead matrix. CONCLUSIONS: From the preliminary results, we can suggest that the highly porous PCL beads may be a promising candidate as a bone filler (scaffolding matrix) for the effective bone regeneration. BioMed Central 2014-11-24 /pmc/articles/PMC4552305/ /pubmed/26331069 http://dx.doi.org/10.1186/2055-7124-18-18 Text en © Byun et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Byun, June-Ho Lee, Han A Reum Kim, Tae Ho Lee, Jin Ho Oh, Se Heang Effect of porous polycaprolactone beads on bone regeneration: preliminary in vitro and in vivo studies |
title | Effect of porous polycaprolactone beads on bone regeneration: preliminary in vitro and in vivo studies |
title_full | Effect of porous polycaprolactone beads on bone regeneration: preliminary in vitro and in vivo studies |
title_fullStr | Effect of porous polycaprolactone beads on bone regeneration: preliminary in vitro and in vivo studies |
title_full_unstemmed | Effect of porous polycaprolactone beads on bone regeneration: preliminary in vitro and in vivo studies |
title_short | Effect of porous polycaprolactone beads on bone regeneration: preliminary in vitro and in vivo studies |
title_sort | effect of porous polycaprolactone beads on bone regeneration: preliminary in vitro and in vivo studies |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552305/ https://www.ncbi.nlm.nih.gov/pubmed/26331069 http://dx.doi.org/10.1186/2055-7124-18-18 |
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