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8-Chloroadenosine Sensitivity in Renal Cell Carcinoma Is Associated with AMPK Activation and mTOR Pathway Inhibition

The adenosine analog 8-chloroadenosine has been shown to deplete ATP and inhibit tumor growth in hematological malignancies as well as in lung and breast cancer cell lines. We investigated effects of 8-chloroadenosine on clear cell (cc) renal cell carcinoma (RCC) cell lines. 8-chloroadenosine was ef...

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Detalles Bibliográficos
Autores principales:	Kearney, Alper Y., Fan, You-Hong, Giri, Uma, Saigal, Babita, Gandhi, Varsha, Heymach, John V., Zurita, Amado J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552467/ https://www.ncbi.nlm.nih.gov/pubmed/26313261 http://dx.doi.org/10.1371/journal.pone.0135962

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