A Novel Prime and Boost Regimen of HIV Virus-Like Particles with TLR4 Adjuvant MPLA Induces Th1 Oriented Immune Responses against HIV

HIV virus-like particles (VLPs) present the HIV envelope protein in its native conformation, providing an ideal vaccine antigen. To enhance the immunogenicity of the VLP vaccine, we sought to improve upon two components; the route of administration and the additional adjuvant. Using HIV VLPs, we eva...

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Detalles Bibliográficos
Autores principales: Poteet, Ethan, Lewis, Phoebe, Li, Feng, Zhang, Sheng, Gu, Jianhua, Chen, Changyi, Ho, Sam On, Do, Thai, Chiang, SuMing, Fujii, Gary, Yao, Qizhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552547/
https://www.ncbi.nlm.nih.gov/pubmed/26312747
http://dx.doi.org/10.1371/journal.pone.0136862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552547/
https://www.ncbi.nlm.nih.gov/pubmed/26312747
http://dx.doi.org/10.1371/journal.pone.0136862

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