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Genomic landscape of cutaneous T cell lymphoma
Cutaneous T cell lymphoma (CTCL) is a non-Hodgkin lymphoma of skin-homing T lymphocytes. We performed exome and whole genome DNA sequence and RNA sequencing on purified CTCL and matched normal cells. The results implicate mutations in 17 genes in CTCL pathogenesis, including genes involved in T cell...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552614/ https://www.ncbi.nlm.nih.gov/pubmed/26192916 http://dx.doi.org/10.1038/ng.3356 |
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author | Choi, Jaehyuk Goh, Gerald Walradt, Trent Hong, Bok S. Bunick, Christopher G. Chen, Kan Bjornson, Robert D. Maman, Yaakov Wang, Tiffany Tordoff, Jesse Carlson, Kacie Overton, John D. Liu, Kristina J. Lewis, Julia M. Devine, Lesley Barbarotta, Lisa Foss, Francine M. Subtil, Antonio Vonderheid, Eric C. Edelson, Richard L. Schatz, David G. Boggon, Titus J. Girardi, Michael Lifton, Richard P. |
author_facet | Choi, Jaehyuk Goh, Gerald Walradt, Trent Hong, Bok S. Bunick, Christopher G. Chen, Kan Bjornson, Robert D. Maman, Yaakov Wang, Tiffany Tordoff, Jesse Carlson, Kacie Overton, John D. Liu, Kristina J. Lewis, Julia M. Devine, Lesley Barbarotta, Lisa Foss, Francine M. Subtil, Antonio Vonderheid, Eric C. Edelson, Richard L. Schatz, David G. Boggon, Titus J. Girardi, Michael Lifton, Richard P. |
author_sort | Choi, Jaehyuk |
collection | PubMed |
description | Cutaneous T cell lymphoma (CTCL) is a non-Hodgkin lymphoma of skin-homing T lymphocytes. We performed exome and whole genome DNA sequence and RNA sequencing on purified CTCL and matched normal cells. The results implicate mutations in 17 genes in CTCL pathogenesis, including genes involved in T cell activation and apoptosis, NFκB signaling, chromatin remodeling, and DNA damage response. CTCL is distinctive in that somatic copy number variants (SCNVs) comprise 92% of all driver mutations (mean of 11.8 pathogenic SCNVs vs. 1.0 somatic single nucleotide variants per CTCL). These findings have implications for novel therapeutics. |
format | Online Article Text |
id | pubmed-4552614 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
record_format | MEDLINE/PubMed |
spelling | pubmed-45526142016-03-01 Genomic landscape of cutaneous T cell lymphoma Choi, Jaehyuk Goh, Gerald Walradt, Trent Hong, Bok S. Bunick, Christopher G. Chen, Kan Bjornson, Robert D. Maman, Yaakov Wang, Tiffany Tordoff, Jesse Carlson, Kacie Overton, John D. Liu, Kristina J. Lewis, Julia M. Devine, Lesley Barbarotta, Lisa Foss, Francine M. Subtil, Antonio Vonderheid, Eric C. Edelson, Richard L. Schatz, David G. Boggon, Titus J. Girardi, Michael Lifton, Richard P. Nat Genet Article Cutaneous T cell lymphoma (CTCL) is a non-Hodgkin lymphoma of skin-homing T lymphocytes. We performed exome and whole genome DNA sequence and RNA sequencing on purified CTCL and matched normal cells. The results implicate mutations in 17 genes in CTCL pathogenesis, including genes involved in T cell activation and apoptosis, NFκB signaling, chromatin remodeling, and DNA damage response. CTCL is distinctive in that somatic copy number variants (SCNVs) comprise 92% of all driver mutations (mean of 11.8 pathogenic SCNVs vs. 1.0 somatic single nucleotide variants per CTCL). These findings have implications for novel therapeutics. 2015-07-20 2015-09 /pmc/articles/PMC4552614/ /pubmed/26192916 http://dx.doi.org/10.1038/ng.3356 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Choi, Jaehyuk Goh, Gerald Walradt, Trent Hong, Bok S. Bunick, Christopher G. Chen, Kan Bjornson, Robert D. Maman, Yaakov Wang, Tiffany Tordoff, Jesse Carlson, Kacie Overton, John D. Liu, Kristina J. Lewis, Julia M. Devine, Lesley Barbarotta, Lisa Foss, Francine M. Subtil, Antonio Vonderheid, Eric C. Edelson, Richard L. Schatz, David G. Boggon, Titus J. Girardi, Michael Lifton, Richard P. Genomic landscape of cutaneous T cell lymphoma |
title | Genomic landscape of cutaneous T cell lymphoma |
title_full | Genomic landscape of cutaneous T cell lymphoma |
title_fullStr | Genomic landscape of cutaneous T cell lymphoma |
title_full_unstemmed | Genomic landscape of cutaneous T cell lymphoma |
title_short | Genomic landscape of cutaneous T cell lymphoma |
title_sort | genomic landscape of cutaneous t cell lymphoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552614/ https://www.ncbi.nlm.nih.gov/pubmed/26192916 http://dx.doi.org/10.1038/ng.3356 |
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