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Genomic landscape of cutaneous T cell lymphoma

Cutaneous T cell lymphoma (CTCL) is a non-Hodgkin lymphoma of skin-homing T lymphocytes. We performed exome and whole genome DNA sequence and RNA sequencing on purified CTCL and matched normal cells. The results implicate mutations in 17 genes in CTCL pathogenesis, including genes involved in T cell...

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Autores principales: Choi, Jaehyuk, Goh, Gerald, Walradt, Trent, Hong, Bok S., Bunick, Christopher G., Chen, Kan, Bjornson, Robert D., Maman, Yaakov, Wang, Tiffany, Tordoff, Jesse, Carlson, Kacie, Overton, John D., Liu, Kristina J., Lewis, Julia M., Devine, Lesley, Barbarotta, Lisa, Foss, Francine M., Subtil, Antonio, Vonderheid, Eric C., Edelson, Richard L., Schatz, David G., Boggon, Titus J., Girardi, Michael, Lifton, Richard P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552614/
https://www.ncbi.nlm.nih.gov/pubmed/26192916
http://dx.doi.org/10.1038/ng.3356
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author Choi, Jaehyuk
Goh, Gerald
Walradt, Trent
Hong, Bok S.
Bunick, Christopher G.
Chen, Kan
Bjornson, Robert D.
Maman, Yaakov
Wang, Tiffany
Tordoff, Jesse
Carlson, Kacie
Overton, John D.
Liu, Kristina J.
Lewis, Julia M.
Devine, Lesley
Barbarotta, Lisa
Foss, Francine M.
Subtil, Antonio
Vonderheid, Eric C.
Edelson, Richard L.
Schatz, David G.
Boggon, Titus J.
Girardi, Michael
Lifton, Richard P.
author_facet Choi, Jaehyuk
Goh, Gerald
Walradt, Trent
Hong, Bok S.
Bunick, Christopher G.
Chen, Kan
Bjornson, Robert D.
Maman, Yaakov
Wang, Tiffany
Tordoff, Jesse
Carlson, Kacie
Overton, John D.
Liu, Kristina J.
Lewis, Julia M.
Devine, Lesley
Barbarotta, Lisa
Foss, Francine M.
Subtil, Antonio
Vonderheid, Eric C.
Edelson, Richard L.
Schatz, David G.
Boggon, Titus J.
Girardi, Michael
Lifton, Richard P.
author_sort Choi, Jaehyuk
collection PubMed
description Cutaneous T cell lymphoma (CTCL) is a non-Hodgkin lymphoma of skin-homing T lymphocytes. We performed exome and whole genome DNA sequence and RNA sequencing on purified CTCL and matched normal cells. The results implicate mutations in 17 genes in CTCL pathogenesis, including genes involved in T cell activation and apoptosis, NFκB signaling, chromatin remodeling, and DNA damage response. CTCL is distinctive in that somatic copy number variants (SCNVs) comprise 92% of all driver mutations (mean of 11.8 pathogenic SCNVs vs. 1.0 somatic single nucleotide variants per CTCL). These findings have implications for novel therapeutics.
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spelling pubmed-45526142016-03-01 Genomic landscape of cutaneous T cell lymphoma Choi, Jaehyuk Goh, Gerald Walradt, Trent Hong, Bok S. Bunick, Christopher G. Chen, Kan Bjornson, Robert D. Maman, Yaakov Wang, Tiffany Tordoff, Jesse Carlson, Kacie Overton, John D. Liu, Kristina J. Lewis, Julia M. Devine, Lesley Barbarotta, Lisa Foss, Francine M. Subtil, Antonio Vonderheid, Eric C. Edelson, Richard L. Schatz, David G. Boggon, Titus J. Girardi, Michael Lifton, Richard P. Nat Genet Article Cutaneous T cell lymphoma (CTCL) is a non-Hodgkin lymphoma of skin-homing T lymphocytes. We performed exome and whole genome DNA sequence and RNA sequencing on purified CTCL and matched normal cells. The results implicate mutations in 17 genes in CTCL pathogenesis, including genes involved in T cell activation and apoptosis, NFκB signaling, chromatin remodeling, and DNA damage response. CTCL is distinctive in that somatic copy number variants (SCNVs) comprise 92% of all driver mutations (mean of 11.8 pathogenic SCNVs vs. 1.0 somatic single nucleotide variants per CTCL). These findings have implications for novel therapeutics. 2015-07-20 2015-09 /pmc/articles/PMC4552614/ /pubmed/26192916 http://dx.doi.org/10.1038/ng.3356 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Choi, Jaehyuk
Goh, Gerald
Walradt, Trent
Hong, Bok S.
Bunick, Christopher G.
Chen, Kan
Bjornson, Robert D.
Maman, Yaakov
Wang, Tiffany
Tordoff, Jesse
Carlson, Kacie
Overton, John D.
Liu, Kristina J.
Lewis, Julia M.
Devine, Lesley
Barbarotta, Lisa
Foss, Francine M.
Subtil, Antonio
Vonderheid, Eric C.
Edelson, Richard L.
Schatz, David G.
Boggon, Titus J.
Girardi, Michael
Lifton, Richard P.
Genomic landscape of cutaneous T cell lymphoma
title Genomic landscape of cutaneous T cell lymphoma
title_full Genomic landscape of cutaneous T cell lymphoma
title_fullStr Genomic landscape of cutaneous T cell lymphoma
title_full_unstemmed Genomic landscape of cutaneous T cell lymphoma
title_short Genomic landscape of cutaneous T cell lymphoma
title_sort genomic landscape of cutaneous t cell lymphoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552614/
https://www.ncbi.nlm.nih.gov/pubmed/26192916
http://dx.doi.org/10.1038/ng.3356
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