Serine Phosphorylation of HIV-1 Vpu and Its Binding to Tetherin Regulates Interaction with Clathrin Adaptors

HIV-1 Vpu prevents incorporation of tetherin (BST2/ CD317) into budding virions and targets it for ESCRT-dependent endosomal degradation via a clathrin-dependent process. This requires a variant acidic dileucine-sorting motif (ExxxLV) in Vpu. Structural studies demonstrate that recombinant Vpu/tethe...

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Detalles Bibliográficos
Autores principales: Kueck, Tonya, Foster, Toshana L., Weinelt, Julia, Sumner, Jonathan C., Pickering, Suzanne, Neil, Stuart J. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552633/
https://www.ncbi.nlm.nih.gov/pubmed/26317613
http://dx.doi.org/10.1371/journal.ppat.1005141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552633/
https://www.ncbi.nlm.nih.gov/pubmed/26317613
http://dx.doi.org/10.1371/journal.ppat.1005141

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