Cargando…

A New Set of Chemical Starting Points with Plasmodium falciparum Transmission-Blocking Potential for Antimalarial Drug Discovery

The discovery of new antimalarials with transmission blocking activity remains a key issue in efforts to control malaria and eventually eradicate the disease. Recently, high-throughput screening (HTS) assays have been successfully applied to Plasmodium falciparum asexual stages to screen millions of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Almela, Maria Jesus, Lozano, Sonia, Lelièvre, Joël, Colmenarejo, Gonzalo, Coterón, José Miguel, Rodrigues, Janneth, Gonzalez, Carolina, Herreros, Esperanza
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552634/ https://www.ncbi.nlm.nih.gov/pubmed/26317851 http://dx.doi.org/10.1371/journal.pone.0135139

Ejemplares similares

Activity of Clinically Relevant Antimalarial Drugs on Plasmodium falciparum Mature Gametocytes in an ATP Bioluminescence “Transmission Blocking” Assay
por: Lelièvre, Joël, et al.
Publicado: (2012)

Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence “transmission blocking” assay
por: Lelièvre, Joël, et al.
Publicado: (2012)

Predicting transmission blocking potential of anti-malarial compounds in the Mosquito Feeding Assay using Plasmodium falciparum Male Gamete Inhibition Assay
por: Colmenarejo, Gonzalo, et al.
Publicado: (2018)

A novel validated assay to support the discovery of new anti-malarial gametocytocidal agents
por: Bahamontes-Rosa, Noemí, et al.
Publicado: (2016)

Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen
por: Miguel-Blanco, Celia, et al.
Publicado: (2017)

Gametocytes from K13 Propeller Mutant Plasmodium falciparum Clinical Isolates Demonstrate Reduced Susceptibility to Dihydroartemisinin in the Male Gamete Exflagellation Inhibition Assay
por: Lozano, Sonia, et al.
Publicado: (2018)

Chemogenomic profiling of Plasmodium falciparum as a tool to aid antimalarial drug discovery
por: Pradhan, Anupam, et al.
Publicado: (2015)

Comparison of the susceptibility of Plasmodium knowlesi and Plasmodium falciparum to antimalarial agents
por: van Schalkwyk, Donelly A, et al.
Publicado: (2017)

Blocking Plasmodium falciparum Malaria Transmission with Drugs: The Gametocytocidal and Sporontocidal Properties of Current and Prospective Antimalarials
por: Kiszewski, Anthony E.
Publicado: (2010)

Antimalarials increase vesicle pH in Plasmodium falciparum
Publicado: (1985)

Validation of Plasmodium falciparum deoxyhypusine synthase as an antimalarial target
por: Aroonsri, Aiyada, et al.
Publicado: (2019)

Extrachromosomal DNA amplicons in antimalarial‐resistant Plasmodium falciparum
por: McDaniels, Jennifer M., et al.
Publicado: (2020)

Plasmodium falciparum Nicotinamidase as A Novel Antimalarial Target
por: Donu, Dickson, et al.
Publicado: (2022)

Prevalence and temporal changes of mutations linked to antimalarial drug resistance in Plasmodium falciparum and Plasmodium vivax in Palawan, Philippines
por: Bareng, Alison Paolo N., et al.
Publicado: (2022)

Comparison and Optimization of Different Methods for the In Vitro Production of Plasmodium falciparum Gametocytes
por: Roncalés, María, et al.
Publicado: (2012)

Sensitivity of Plasmodium falciparum to Antimalarial Drugs in Hainan Island, China
por: Wang, Shan-Qing, et al.
Publicado: (2015)

The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC
por: Verity, Robert, et al.
Publicado: (2020)

Robenidine Analogues Are Potent Antimalarials in Drug-Resistant Plasmodium falciparum
por: Krollenbrock, Alina, et al.
Publicado: (2021)

Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline
por: Kreutzfeld, Oriana, et al.
Publicado: (2023)

Red blood cells derived from peripheral blood and bone marrow CD34+ human haematopoietic stem cells are permissive to Plasmodium parasites infection
por: Fernandez-Becerra, Carmen, et al.
Publicado: (2013)

Plasmodium falciparum Thioredoxin Reductase (PfTrxR) and Its Role as a Target for New Antimalarial Discovery
por: McCarty, Sara E., et al.
Publicado: (2015)

Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance
por: Shahinas, Dea, et al.
Publicado: (2013)

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity
por: Kokkonda, Sreekanth, et al.
Publicado: (2018)

Genomic Epidemiology of Antimalarial Drug Resistance in Plasmodium falciparum in Southern China
por: Huang, Fang, et al.
Publicado: (2021)

Targeting the Plasmodium falciparum proteome and organelles for potential antimalarial drug candidates
por: Abugri, James, et al.
Publicado: (2022)

Plasmodium falciparum merozoite invasion ligands, linked antimalarial resistance loci and ex vivo responses to antimalarials in The Gambia
por: Mbye, Haddijatou, et al.
Publicado: (2022)

How is childhood development of immunity to Plasmodium falciparum enhanced by certain antimalarial interventions?
por: Sutherland, Colin J, et al.
Publicado: (2007)

Epidemic of Plasmodium falciparum Malaria Involving Substandard Antimalarial Drugs, Pakistan, 2003
por: Leslie, Toby, et al.
Publicado: (2009)

Antimalarial activity of ulein and proof of its action on the Plasmodium falciparum digestive vacuole
por: de Oliveira, Alaíde Braga, et al.
Publicado: (2010)

Serine Proteases of Malaria Parasite Plasmodium falciparum: Potential as Antimalarial Drug Targets
por: Alam, Asrar
Publicado: (2014)

Pyrazoleamide compounds are potent antimalarials that target Na(+) homeostasis in intraerythrocytic Plasmodium falciparum
por: Vaidya, Akhil B., et al.
Publicado: (2014)

In vitro susceptibility of Indian Plasmodium falciparum isolates to different antimalarial drugs & antibiotics
por: Agarwal, Pooja, et al.
Publicado: (2017)

Antimalarial activity of Malaria Box Compounds against Plasmodium falciparum clinical isolates
por: Chirawurah, Jersley D., et al.
Publicado: (2017)

Modelling the impact of antimalarial quality on the transmission of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum
por: Brock, Aleisha R., et al.
Publicado: (2017)

Evaluating antimalarial efficacy by tracking glycolysis in Plasmodium falciparum using NMR spectroscopy
por: Shivapurkar, Rupali, et al.
Publicado: (2018)

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway
por: LaMonte, Gregory M., et al.
Publicado: (2020)

PERSISTENCE OF PLASMODIUM FALCIPARUM HRP2 ANTIGEN AFTER EFFECTIVE ANTIMALARIAL THERAPY
por: Michael, O.S., et al.
Publicado: (2021)

Antimalarial drug resistance—is it time to re-evaluate Plasmodium falciparum orthologous genes?
por: Khattak, Aamer Ali, et al.
Publicado: (2022)

In Silico and In Vitro Antimalarial Screening and Validation Targeting Plasmodium falciparum Plasmepsin V
por: Ji, Xin, et al.
Publicado: (2022)

Exposing Anopheles mosquitoes to antimalarials blocks Plasmodium parasite transmission
por: Paton, Douglas G., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_9r77qv53utbpfnv8q24uloogg8