The bacterial pangenome as a new tool for analysing pathogenic bacteria

The bacterial pangenome was introduced in 2005 and, in recent years, has been the subject of many studies. Thanks to progress in next-generation sequencing methods, the pangenome can be divided into two parts, the core (common to the studied strains) and the accessory genome, offering a large panel...

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Detalles Bibliográficos
Autores principales: Rouli, L., Merhej, V., Fournier, P.-E., Raoult, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552756/
https://www.ncbi.nlm.nih.gov/pubmed/26442149
http://dx.doi.org/10.1016/j.nmni.2015.06.005
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author Rouli, L.
Merhej, V.
Fournier, P.-E.
Raoult, D.
author_facet Rouli, L.
Merhej, V.
Fournier, P.-E.
Raoult, D.
author_sort Rouli, L.
collection PubMed
description The bacterial pangenome was introduced in 2005 and, in recent years, has been the subject of many studies. Thanks to progress in next-generation sequencing methods, the pangenome can be divided into two parts, the core (common to the studied strains) and the accessory genome, offering a large panel of uses. In this review, we have presented the analysis methods, the pangenome composition and its application as a study of lifestyle. We have also shown that the pangenome may be used as a new tool for redefining the pathogenic species. We applied this to the Escherichia coli and Shigella species, which have been a subject of controversy regarding their taxonomic and pathogenic position.
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spelling pubmed-45527562015-10-05 The bacterial pangenome as a new tool for analysing pathogenic bacteria Rouli, L. Merhej, V. Fournier, P.-E. Raoult, D. New Microbes New Infect Original Article The bacterial pangenome was introduced in 2005 and, in recent years, has been the subject of many studies. Thanks to progress in next-generation sequencing methods, the pangenome can be divided into two parts, the core (common to the studied strains) and the accessory genome, offering a large panel of uses. In this review, we have presented the analysis methods, the pangenome composition and its application as a study of lifestyle. We have also shown that the pangenome may be used as a new tool for redefining the pathogenic species. We applied this to the Escherichia coli and Shigella species, which have been a subject of controversy regarding their taxonomic and pathogenic position. Elsevier 2015-06-26 /pmc/articles/PMC4552756/ /pubmed/26442149 http://dx.doi.org/10.1016/j.nmni.2015.06.005 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Rouli, L.
Merhej, V.
Fournier, P.-E.
Raoult, D.
The bacterial pangenome as a new tool for analysing pathogenic bacteria
title The bacterial pangenome as a new tool for analysing pathogenic bacteria
title_full The bacterial pangenome as a new tool for analysing pathogenic bacteria
title_fullStr The bacterial pangenome as a new tool for analysing pathogenic bacteria
title_full_unstemmed The bacterial pangenome as a new tool for analysing pathogenic bacteria
title_short The bacterial pangenome as a new tool for analysing pathogenic bacteria
title_sort bacterial pangenome as a new tool for analysing pathogenic bacteria
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552756/
https://www.ncbi.nlm.nih.gov/pubmed/26442149
http://dx.doi.org/10.1016/j.nmni.2015.06.005
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