Cargando…

DNA-Launched Alphavirus Replicons Encoding a Fusion of Mycobacterial Antigens Acr and Ag85B Are Immunogenic and Protective in a Murine Model of TB Infection

There is an urgent need for effective prophylactic measures against Mycobacterium tuberculosis (Mtb) infection, particularly given the highly variable efficacy of Bacille Calmette-Guerin (BCG), the only licensed vaccine against tuberculosis (TB). Most studies indicate that cell-mediated immune respo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dalmia, Neha, Klimstra, William B., Mason, Carol, Ramsay, Alistair J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552820/ https://www.ncbi.nlm.nih.gov/pubmed/26317509 http://dx.doi.org/10.1371/journal.pone.0136635

Ejemplares similares

The Adjuvant Activity of Alphavirus Replicons Is Enhanced by Incorporating the Microbial Molecule Flagellin into the Replicon
por: Knudsen, Maria L., et al.
Publicado: (2013)

A Vaccinia Virus Recombinant Transcribing an Alphavirus Replicon and Expressing Alphavirus Structural Proteins Leads to Packaging of Alphavirus Infectious Single Cycle Particles
por: Sánchez-Puig, Juana M., et al.
Publicado: (2013)

Development and characterization of promoterless helper RNAs for the production of alphavirus replicon particle
por: Kamrud, K. I., et al.
Publicado: (2010)

Immunogenicity of a DNA-launched replicon-based canine parvovirus DNA vaccine expressing VP2 antigen in dogs
por: Dahiya, Shyam S., et al.
Publicado: (2012)

Comparison of the Immunogenic Properties of Lactiplantibacillus plantarum Carrying the Mycobacterial Ag85B-ESAT-6 Antigen at Various Cellular Localizations
por: Wiull, Kamilla, et al.
Publicado: (2022)

P19-14. Recombinant alphavirus replicon particles as a platform to evaluate immunogenicity of early transmitted clade C virus envelopes
por: Franti, M, et al.
Publicado: (2009)

Expression and Immunogenicity of the Mycobacterial Ag85B/ESAT-6 Antigens Produced in Transgenic Plants by Elastin-Like Peptide Fusion Strategy
por: Floss, Doreen Manuela, et al.
Publicado: (2010)

Optimising Immunogenicity with Viral Vectors: Mixing MVA and HAdV-5 Expressing the Mycobacterial Antigen Ag85A in a Single Injection
por: Betts, Gareth, et al.
Publicado: (2012)

Immunogenicity and Protective Efficacy of a Novel Recombinant BCG Strain Overexpressing Antigens Ag85A and Ag85B
por: Wang, Chun, et al.
Publicado: (2012)

Alphavirus vector-based replicon particles expressing multivalent cross-protective Lassa virus glycoproteins
por: Wang, Min, et al.
Publicado: (2017)

Alphavirus replicon particles containing the gene for HER2/neu inhibit breast cancer growth and tumorigenesis
por: Wang, Xiaoyan, et al.
Publicado: (2005)

Protection associated with a TB vaccine is linked to increased frequency of Ag85A-specific CD4(+) T cells but no increase in avidity for Ag85A
por: Metcalfe, Hannah J., et al.
Publicado: (2016)

Rapid, Specific Detection of Alphaviruses from Tissue Cultures Using a Replicon-Defective Reporter Gene Assay
por: Li, Jiangjiao, et al.
Publicado: (2012)

Inhibitors of Alphavirus Entry and Replication Identified with a Stable Chikungunya Replicon Cell Line and Virus-Based Assays
por: Pohjala, Leena, et al.
Publicado: (2011)

Selection of a Single Domain Antibody, Specific for an HLA-Bound Epitope of the Mycobacterial Ag85B Antigen
por: Ortega, Paola A., et al.
Publicado: (2020)

Correction: Rapid, Specific Detection of Alphaviruses from Tissue Cultures Using a Replicon-Defective Reporter Gene Assay
por: Li, Jiangjiao, et al.
Publicado: (2012)

Characterization of untranslated regions of the salmonid alphavirus 3 (SAV3) genome and construction of a SAV3 based replicon
por: Karlsen, Marius, et al.
Publicado: (2009)

Development and characterization of a Rift Valley fever virus cell–cell fusion assay using alphavirus replicon vectors
por: Filone, Claire Marie, et al.
Publicado: (2006)

Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines
por: Diebold, Sandra S., et al.
Publicado: (2008)

Immunogenicity of a Fusion Protein Containing Immunodominant Epitopes of Ag85C, MPT51, and HspX from Mycobacterium tuberculosis in Mice and Active TB Infection
por: de Sousa, Eduardo Martins, et al.
Publicado: (2012)

Alphavirus Replicon Particles Expressing TRP-2 Provide Potent Therapeutic Effect on Melanoma through Activation of Humoral and Cellular Immunity
por: Avogadri, Francesca, et al.
Publicado: (2010)

Alphavirus Replicon DNA Vectors Expressing Ebola GP and VP40 Antigens Induce Humoral and Cellular Immune Responses in Mice
por: Ren, Shoufeng, et al.
Publicado: (2018)

Potent therapeutic efficacy of an alphavirus replicon DNA vaccine expressing human papilloma virus E6 and E7 antigens
por: van de Wall, Stephanie, et al.
Publicado: (2018)

Correction: Immunogenicity of a Fusion Protein Containing Immunodominant Epitopes of Ag85C, MPT51, and HspX from Mycobacterium tuberculosis in Mice and Active TB Infection
por: de Sousa, Eduardo Martins, et al.
Publicado: (2013)

Prime-boost regimen potency and efficacy with alphavirus replicons (SIV antigen) in non-human primates challenged with low-dose intra-rectal SIVsmE660
por: Banerjee, K, et al.
Publicado: (2012)

Role of innate signalling pathways in the immunogenicity of alphaviral replicon-based vaccines
por: Näslund, Tanja I, et al.
Publicado: (2011)

Electrocardiography Abnormalities in Macaques after Infection with Encephalitic Alphaviruses
por: Ma, Henry, et al.
Publicado: (2019)

Comparing the safety and immunogenicity of a candidate TB vaccine MVA85A administered by intramuscular and intradermal delivery()
por: Meyer, Joel, et al.
Publicado: (2013)

Comparison of the Predicted Population Coverage of Tuberculosis Vaccine Candidates Ag85B-ESAT-6, Ag85B-TB10.4, and Mtb72f via a Bioinformatics Approach
por: Davila, Jose, et al.
Publicado: (2012)

A Polyprotein-Expressing Salmonid Alphavirus Replicon Induces Modest Protection in Atlantic Salmon (Salmo Salar) Against Infectious Pancreatic Necrosis
por: Abdullah, Azila, et al.
Publicado: (2015)

An alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates
por: Erasmus, Jesse H., et al.
Publicado: (2020)

A mouse model for SARS-CoV-2 infection by exogenous delivery of hACE2 using alphavirus replicon particles
por: Zhang, Ya-Nan, et al.
Publicado: (2020)

Alphavirus Replicon Particle Vaccine Breaks B Cell Tolerance and Rapidly Induces IgG to Murine Hematolymphoid Tumor Associated Antigens
por: Su, Hsuan, et al.
Publicado: (2022)

Phase I Trial Evaluating the Safety and Immunogenicity of Candidate TB Vaccine MVA85A, Delivered by Aerosol to Healthy M.tb-Infected Adults
por: Riste, Michael, et al.
Publicado: (2021)

DNA-launched RNA replicon vaccines induce potent anti-SARS-CoV-2 immune responses in mice
por: Szurgot, Inga, et al.
Publicado: (2021)

Correction: Comparison of the Predicted Population Coverage of Tuberculosis Vaccine Candidates Ag85B-ESAT-6, Ag85B-TB10.4, and Mtb72f via a Bioinformatics Approach
por: Davila, Jose, et al.
Publicado: (2012)

Mechanical Forces between Mycobacterial Antigen 85 Complex and Fibronectin
por: Viljoen, Albertus, et al.
Publicado: (2020)

Immunization with an adenovirus-vectored TB vaccine containing Ag85A-Mtb32 effectively alleviates allergic asthma
por: Zhang, Yiling, et al.
Publicado: (2018)

A Novel System for the Launch of Alphavirus RNA Synthesis Reveals a Role for the Imd Pathway in Arthropod Antiviral Response
por: Avadhanula, Vasanthi, et al.
Publicado: (2009)

An alphavirus replicon particle delivering prefusion-stabilized spike protein provides potent immunoprotection against SARS-CoV-2 Omicron variant
por: Zhang, Hong-Qing, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_43lvc9p14nlkci75uv7utub9ap