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Delayed and disorganised brain activation detected with magnetoencephalography after mild traumatic brain injury
BACKGROUND: Awareness to neurocognitive issues after mild traumatic brain injury (mTBI) is increasing, but currently no imaging markers are available for mTBI. Advanced structural imaging recently showed microstructural tissue changes and axonal injury, mild but likely sufficient to lead to function...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552930/ https://www.ncbi.nlm.nih.gov/pubmed/25324505 http://dx.doi.org/10.1136/jnnp-2014-308571 |
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author | da Costa, Leodante Robertson, Amanda Bethune, Allison MacDonald, Matt J Shek, Pang N Taylor, Margot J Pang, Elizabeth W |
author_facet | da Costa, Leodante Robertson, Amanda Bethune, Allison MacDonald, Matt J Shek, Pang N Taylor, Margot J Pang, Elizabeth W |
author_sort | da Costa, Leodante |
collection | PubMed |
description | BACKGROUND: Awareness to neurocognitive issues after mild traumatic brain injury (mTBI) is increasing, but currently no imaging markers are available for mTBI. Advanced structural imaging recently showed microstructural tissue changes and axonal injury, mild but likely sufficient to lead to functional deficits. Magnetoencephalography (MEG) has high temporal and spatial resolution, combining structural and electrophysiological information, and can be used to examine brain activation patterns of regions involved with specific tasks. METHODS: 16 adults with mTBI and 16 matched controls were submitted to neuropsychological testing (Wechsler Abbreviated Scale of Intelligence (WASI); Conners; Alcohol Use Disorders Identification Test (AUDIT); Generalised Anxiety Disorder Seven-item Scale (GAD-7); Patient Health Questionnaire (PHQ-9); Symptom Checklist and Symptom Severity Score (SCAT2)) and MEG while tested for mental flexibility (Intra-Extra Dimensional set-shifting tasks). Three-dimensional maps were generated using synthetic aperture magnetometry beamforming analyses to identify differences in regional activation and activation times. Reaction times and accuracy between groups were compared using 2×2 mixed analysis of variance. FINDINGS: While accuracy was similar, patients with mTBI reaction time was delayed and sequence of activation of brain regions disorganised, with involvement of extra regions such as the occipital lobes, not used by controls. Examination of activation time showed significant delays in the right insula and left posterior parietal cortex in patients with mTBI. CONCLUSIONS: Patients with mTBI showed significant delays in the activation of important areas involved in executive function. Also, more regions of the brain are involved in an apparent compensatory effort. Our study suggests that MEG can detect subtle neural changes associated with cognitive dysfunction and thus, may eventually be useful for capturing and tracking the onset and course of cognitive symptoms associated with mTBI. |
format | Online Article Text |
id | pubmed-4552930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-45529302015-09-02 Delayed and disorganised brain activation detected with magnetoencephalography after mild traumatic brain injury da Costa, Leodante Robertson, Amanda Bethune, Allison MacDonald, Matt J Shek, Pang N Taylor, Margot J Pang, Elizabeth W J Neurol Neurosurg Psychiatry Neurosurgery BACKGROUND: Awareness to neurocognitive issues after mild traumatic brain injury (mTBI) is increasing, but currently no imaging markers are available for mTBI. Advanced structural imaging recently showed microstructural tissue changes and axonal injury, mild but likely sufficient to lead to functional deficits. Magnetoencephalography (MEG) has high temporal and spatial resolution, combining structural and electrophysiological information, and can be used to examine brain activation patterns of regions involved with specific tasks. METHODS: 16 adults with mTBI and 16 matched controls were submitted to neuropsychological testing (Wechsler Abbreviated Scale of Intelligence (WASI); Conners; Alcohol Use Disorders Identification Test (AUDIT); Generalised Anxiety Disorder Seven-item Scale (GAD-7); Patient Health Questionnaire (PHQ-9); Symptom Checklist and Symptom Severity Score (SCAT2)) and MEG while tested for mental flexibility (Intra-Extra Dimensional set-shifting tasks). Three-dimensional maps were generated using synthetic aperture magnetometry beamforming analyses to identify differences in regional activation and activation times. Reaction times and accuracy between groups were compared using 2×2 mixed analysis of variance. FINDINGS: While accuracy was similar, patients with mTBI reaction time was delayed and sequence of activation of brain regions disorganised, with involvement of extra regions such as the occipital lobes, not used by controls. Examination of activation time showed significant delays in the right insula and left posterior parietal cortex in patients with mTBI. CONCLUSIONS: Patients with mTBI showed significant delays in the activation of important areas involved in executive function. Also, more regions of the brain are involved in an apparent compensatory effort. Our study suggests that MEG can detect subtle neural changes associated with cognitive dysfunction and thus, may eventually be useful for capturing and tracking the onset and course of cognitive symptoms associated with mTBI. BMJ Publishing Group 2015-09 2014-10-16 /pmc/articles/PMC4552930/ /pubmed/25324505 http://dx.doi.org/10.1136/jnnp-2014-308571 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Neurosurgery da Costa, Leodante Robertson, Amanda Bethune, Allison MacDonald, Matt J Shek, Pang N Taylor, Margot J Pang, Elizabeth W Delayed and disorganised brain activation detected with magnetoencephalography after mild traumatic brain injury |
title | Delayed and disorganised brain activation detected with magnetoencephalography after mild traumatic brain injury |
title_full | Delayed and disorganised brain activation detected with magnetoencephalography after mild traumatic brain injury |
title_fullStr | Delayed and disorganised brain activation detected with magnetoencephalography after mild traumatic brain injury |
title_full_unstemmed | Delayed and disorganised brain activation detected with magnetoencephalography after mild traumatic brain injury |
title_short | Delayed and disorganised brain activation detected with magnetoencephalography after mild traumatic brain injury |
title_sort | delayed and disorganised brain activation detected with magnetoencephalography after mild traumatic brain injury |
topic | Neurosurgery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552930/ https://www.ncbi.nlm.nih.gov/pubmed/25324505 http://dx.doi.org/10.1136/jnnp-2014-308571 |
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