Deciphering the Non-Equivalence of Serine and Threonine O-Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti-MUC1 Antibody**

The structural features of MUC1-like glycopeptides bearing the Tn antigen (α-O-GalNAc-Ser/Thr) in complex with an anti MUC-1 antibody are reported at atomic resolution. For the α-O-GalNAc-Ser derivative, the glycosidic linkage adopts a high-energy conformation, barely populated in the free state. Th...

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Detalles Bibliográficos
Autores principales: Martínez-Sáez, Nuria, Castro-López, Jorge, Valero-González, Jessika, Madariaga, David, Compañón, Ismael, Somovilla, Víctor J, Salvadó, Míriam, Asensio, Juan L, Jiménez-Barbero, Jesús, Avenoza, Alberto, Busto, Jesús H, Bernardes, Gonçalo J L, Peregrina, Jesús M, Hurtado-Guerrero, Ramón, Corzana, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552995/
https://www.ncbi.nlm.nih.gov/pubmed/26118689
http://dx.doi.org/10.1002/anie.201502813

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