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Hearing Assessment after Treatment of Nasopharyngeal Carcinoma with CRT and IMRT Techniques

Objectives. This study analyzed the long-term hearing loss after treatment of primary nasopharyngeal carcinoma to elucidate its causal factors. Methods. Ninety-two nasopharyngeal carcinoma patients were treated with radiotherapy or chemoradiotherapy. Pure tone audiometry was performed before the the...

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Autores principales: Hwang, Chung-Feng, Fang, Fu-Min, Zhuo, Ming-Ying, Yang, Chao-Hui, Yang, Li-Na, Hsieh, Hui-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553178/
https://www.ncbi.nlm.nih.gov/pubmed/26351638
http://dx.doi.org/10.1155/2015/769806
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author Hwang, Chung-Feng
Fang, Fu-Min
Zhuo, Ming-Ying
Yang, Chao-Hui
Yang, Li-Na
Hsieh, Hui-Shan
author_facet Hwang, Chung-Feng
Fang, Fu-Min
Zhuo, Ming-Ying
Yang, Chao-Hui
Yang, Li-Na
Hsieh, Hui-Shan
author_sort Hwang, Chung-Feng
collection PubMed
description Objectives. This study analyzed the long-term hearing loss after treatment of primary nasopharyngeal carcinoma to elucidate its causal factors. Methods. Ninety-two nasopharyngeal carcinoma patients were treated with radiotherapy or chemoradiotherapy. Pure tone audiometry was performed before the therapy and annually up to 9 years after completing treatment. The hearing thresholds were corrected for age-related deterioration and compared to the results without adjusting for age. Results. The mean air and bone conduction threshold with and without correction for age-related deterioration differed significantly 2–9 years after completing radiotherapy (p < 0.05). The audiometry results with age correction showed a flattened configuration compared to the results without age correction. The total radiation dose and radiation modality showed a causal relationship with a greater incidence of hearing loss after therapy (p < 0.05). There was more deterioration in the air and bone hearing thresholds with conformal radiotherapy than intensity-modulated radiotherapy (p < 0.001). A radiation dose >72 cGy resulted in more severe hearing loss than <72 cGy (p < 0.05). Conclusion. Hearing loss after completing therapy should be corrected for age-related hearing deterioration to reveal the true extent to which the loss is a therapeutic complication. Both the radiation modality used and the dose were significantly associated with hearing loss.
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spelling pubmed-45531782015-09-08 Hearing Assessment after Treatment of Nasopharyngeal Carcinoma with CRT and IMRT Techniques Hwang, Chung-Feng Fang, Fu-Min Zhuo, Ming-Ying Yang, Chao-Hui Yang, Li-Na Hsieh, Hui-Shan Biomed Res Int Clinical Study Objectives. This study analyzed the long-term hearing loss after treatment of primary nasopharyngeal carcinoma to elucidate its causal factors. Methods. Ninety-two nasopharyngeal carcinoma patients were treated with radiotherapy or chemoradiotherapy. Pure tone audiometry was performed before the therapy and annually up to 9 years after completing treatment. The hearing thresholds were corrected for age-related deterioration and compared to the results without adjusting for age. Results. The mean air and bone conduction threshold with and without correction for age-related deterioration differed significantly 2–9 years after completing radiotherapy (p < 0.05). The audiometry results with age correction showed a flattened configuration compared to the results without age correction. The total radiation dose and radiation modality showed a causal relationship with a greater incidence of hearing loss after therapy (p < 0.05). There was more deterioration in the air and bone hearing thresholds with conformal radiotherapy than intensity-modulated radiotherapy (p < 0.001). A radiation dose >72 cGy resulted in more severe hearing loss than <72 cGy (p < 0.05). Conclusion. Hearing loss after completing therapy should be corrected for age-related hearing deterioration to reveal the true extent to which the loss is a therapeutic complication. Both the radiation modality used and the dose were significantly associated with hearing loss. Hindawi Publishing Corporation 2015 2015-08-16 /pmc/articles/PMC4553178/ /pubmed/26351638 http://dx.doi.org/10.1155/2015/769806 Text en Copyright © 2015 Chung-Feng Hwang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Hwang, Chung-Feng
Fang, Fu-Min
Zhuo, Ming-Ying
Yang, Chao-Hui
Yang, Li-Na
Hsieh, Hui-Shan
Hearing Assessment after Treatment of Nasopharyngeal Carcinoma with CRT and IMRT Techniques
title Hearing Assessment after Treatment of Nasopharyngeal Carcinoma with CRT and IMRT Techniques
title_full Hearing Assessment after Treatment of Nasopharyngeal Carcinoma with CRT and IMRT Techniques
title_fullStr Hearing Assessment after Treatment of Nasopharyngeal Carcinoma with CRT and IMRT Techniques
title_full_unstemmed Hearing Assessment after Treatment of Nasopharyngeal Carcinoma with CRT and IMRT Techniques
title_short Hearing Assessment after Treatment of Nasopharyngeal Carcinoma with CRT and IMRT Techniques
title_sort hearing assessment after treatment of nasopharyngeal carcinoma with crt and imrt techniques
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553178/
https://www.ncbi.nlm.nih.gov/pubmed/26351638
http://dx.doi.org/10.1155/2015/769806
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