Immune-mediated Liver Injury in Hepatitis B Virus Infection

Hepatitis B virus (HBV) is responsible for approximately 350 million chronic infections worldwide and is a leading cause of broad-spectrum liver diseases such as hepatitis, cirrhosis and liver cancer. Although it has been well established that adaptive immunity plays a critical role in viral clearan...

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Detalles Bibliográficos
Autores principales: Oh, In Soo, Park, Su-Hyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553257/
https://www.ncbi.nlm.nih.gov/pubmed/26330805
http://dx.doi.org/10.4110/in.2015.15.4.191
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author Oh, In Soo
Park, Su-Hyung
author_facet Oh, In Soo
Park, Su-Hyung
author_sort Oh, In Soo
collection PubMed
description Hepatitis B virus (HBV) is responsible for approximately 350 million chronic infections worldwide and is a leading cause of broad-spectrum liver diseases such as hepatitis, cirrhosis and liver cancer. Although it has been well established that adaptive immunity plays a critical role in viral clearance, the pathogenetic mechanisms that cause liver damage during acute and chronic HBV infection remain largely known. This review describes our current knowledge of the immune-mediated pathogenesis of HBV infection and the role of immune cells in the liver injury during hepatitis B.
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spelling pubmed-45532572015-09-01 Immune-mediated Liver Injury in Hepatitis B Virus Infection Oh, In Soo Park, Su-Hyung Immune Netw Review Article Hepatitis B virus (HBV) is responsible for approximately 350 million chronic infections worldwide and is a leading cause of broad-spectrum liver diseases such as hepatitis, cirrhosis and liver cancer. Although it has been well established that adaptive immunity plays a critical role in viral clearance, the pathogenetic mechanisms that cause liver damage during acute and chronic HBV infection remain largely known. This review describes our current knowledge of the immune-mediated pathogenesis of HBV infection and the role of immune cells in the liver injury during hepatitis B. The Korean Association of Immunologists 2015-08 2015-08-26 /pmc/articles/PMC4553257/ /pubmed/26330805 http://dx.doi.org/10.4110/in.2015.15.4.191 Text en Copyright © 2015 The Korean Association of Immunologists http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Oh, In Soo
Park, Su-Hyung
Immune-mediated Liver Injury in Hepatitis B Virus Infection
title Immune-mediated Liver Injury in Hepatitis B Virus Infection
title_full Immune-mediated Liver Injury in Hepatitis B Virus Infection
title_fullStr Immune-mediated Liver Injury in Hepatitis B Virus Infection
title_full_unstemmed Immune-mediated Liver Injury in Hepatitis B Virus Infection
title_short Immune-mediated Liver Injury in Hepatitis B Virus Infection
title_sort immune-mediated liver injury in hepatitis b virus infection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553257/
https://www.ncbi.nlm.nih.gov/pubmed/26330805
http://dx.doi.org/10.4110/in.2015.15.4.191
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AT parksuhyung immunemediatedliverinjuryinhepatitisbvirusinfection

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