Biogenesis, delivery, and function of extracellular RNA

The Extracellular RNA (exRNA) Communication Consortium was launched by the National Institutes of Health to focus on the extent to which RNA might function in a non-cell-autonomous manner. With the availability of increasingly sensitive tools, small amounts of RNA can be detected in serum, plasma, a...

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Detalles Bibliográficos
Autores principales: Patton, James G., Franklin, Jeffrey L., Weaver, Alissa M., Vickers, Kasey, Zhang, Bing, Coffey, Robert J., Ansel, K. Mark, Blelloch, Robert, Goga, Andrei, Huang, Bo, L'Etoille, Noelle, Raffai, Robert L., Lai, Charles P., Krichevsky, Anna M., Mateescu, Bogdan, Greiner, Vanille J., Hunter, Craig, Voinnet, Olivier, McManus, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Co-Action Publishing 2015
Materias:
Special Issue: Extracellular RNA Communication Consortium
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553266/
https://www.ncbi.nlm.nih.gov/pubmed/26320939
http://dx.doi.org/10.3402/jev.v4.27494
Descripción
Sumario:The Extracellular RNA (exRNA) Communication Consortium was launched by the National Institutes of Health to focus on the extent to which RNA might function in a non-cell-autonomous manner. With the availability of increasingly sensitive tools, small amounts of RNA can be detected in serum, plasma, and other bodily fluids. The exact mechanism(s) by which RNA can be secreted from cells and the mechanisms for the delivery and uptake by recipient cells remain to be determined. This review will summarize current knowledge about the biogenesis and delivery of exRNA and outline projects seeking to understand the functional impact of exRNA.

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