Biogenesis, delivery, and function of extracellular RNA

The Extracellular RNA (exRNA) Communication Consortium was launched by the National Institutes of Health to focus on the extent to which RNA might function in a non-cell-autonomous manner. With the availability of increasingly sensitive tools, small amounts of RNA can be detected in serum, plasma, a...

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Autores principales: Patton, James G., Franklin, Jeffrey L., Weaver, Alissa M., Vickers, Kasey, Zhang, Bing, Coffey, Robert J., Ansel, K. Mark, Blelloch, Robert, Goga, Andrei, Huang, Bo, L'Etoille, Noelle, Raffai, Robert L., Lai, Charles P., Krichevsky, Anna M., Mateescu, Bogdan, Greiner, Vanille J., Hunter, Craig, Voinnet, Olivier, McManus, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Co-Action Publishing 2015
Materias:
Special Issue: Extracellular RNA Communication Consortium
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553266/
https://www.ncbi.nlm.nih.gov/pubmed/26320939
http://dx.doi.org/10.3402/jev.v4.27494
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author Patton, James G.
Franklin, Jeffrey L.
Weaver, Alissa M.
Vickers, Kasey
Zhang, Bing
Coffey, Robert J.
Ansel, K. Mark
Blelloch, Robert
Goga, Andrei
Huang, Bo
L'Etoille, Noelle
Raffai, Robert L.
Lai, Charles P.
Krichevsky, Anna M.
Mateescu, Bogdan
Greiner, Vanille J.
Hunter, Craig
Voinnet, Olivier
McManus, Michael T.
author_facet Patton, James G.
Franklin, Jeffrey L.
Weaver, Alissa M.
Vickers, Kasey
Zhang, Bing
Coffey, Robert J.
Ansel, K. Mark
Blelloch, Robert
Goga, Andrei
Huang, Bo
L'Etoille, Noelle
Raffai, Robert L.
Lai, Charles P.
Krichevsky, Anna M.
Mateescu, Bogdan
Greiner, Vanille J.
Hunter, Craig
Voinnet, Olivier
McManus, Michael T.
author_sort Patton, James G.
collection PubMed
description The Extracellular RNA (exRNA) Communication Consortium was launched by the National Institutes of Health to focus on the extent to which RNA might function in a non-cell-autonomous manner. With the availability of increasingly sensitive tools, small amounts of RNA can be detected in serum, plasma, and other bodily fluids. The exact mechanism(s) by which RNA can be secreted from cells and the mechanisms for the delivery and uptake by recipient cells remain to be determined. This review will summarize current knowledge about the biogenesis and delivery of exRNA and outline projects seeking to understand the functional impact of exRNA.
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spelling pubmed-45532662015-09-22 Biogenesis, delivery, and function of extracellular RNA Patton, James G. Franklin, Jeffrey L. Weaver, Alissa M. Vickers, Kasey Zhang, Bing Coffey, Robert J. Ansel, K. Mark Blelloch, Robert Goga, Andrei Huang, Bo L'Etoille, Noelle Raffai, Robert L. Lai, Charles P. Krichevsky, Anna M. Mateescu, Bogdan Greiner, Vanille J. Hunter, Craig Voinnet, Olivier McManus, Michael T. J Extracell Vesicles Special Issue: Extracellular RNA Communication Consortium The Extracellular RNA (exRNA) Communication Consortium was launched by the National Institutes of Health to focus on the extent to which RNA might function in a non-cell-autonomous manner. With the availability of increasingly sensitive tools, small amounts of RNA can be detected in serum, plasma, and other bodily fluids. The exact mechanism(s) by which RNA can be secreted from cells and the mechanisms for the delivery and uptake by recipient cells remain to be determined. This review will summarize current knowledge about the biogenesis and delivery of exRNA and outline projects seeking to understand the functional impact of exRNA. Co-Action Publishing 2015-08-28 /pmc/articles/PMC4553266/ /pubmed/26320939 http://dx.doi.org/10.3402/jev.v4.27494 Text en © 2015 James G. Patton et al. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special Issue: Extracellular RNA Communication Consortium
Patton, James G.
Franklin, Jeffrey L.
Weaver, Alissa M.
Vickers, Kasey
Zhang, Bing
Coffey, Robert J.
Ansel, K. Mark
Blelloch, Robert
Goga, Andrei
Huang, Bo
L'Etoille, Noelle
Raffai, Robert L.
Lai, Charles P.
Krichevsky, Anna M.
Mateescu, Bogdan
Greiner, Vanille J.
Hunter, Craig
Voinnet, Olivier
McManus, Michael T.
Biogenesis, delivery, and function of extracellular RNA
title Biogenesis, delivery, and function of extracellular RNA
title_full Biogenesis, delivery, and function of extracellular RNA
title_fullStr Biogenesis, delivery, and function of extracellular RNA
title_full_unstemmed Biogenesis, delivery, and function of extracellular RNA
title_short Biogenesis, delivery, and function of extracellular RNA
title_sort biogenesis, delivery, and function of extracellular rna
topic Special Issue: Extracellular RNA Communication Consortium
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553266/
https://www.ncbi.nlm.nih.gov/pubmed/26320939
http://dx.doi.org/10.3402/jev.v4.27494
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