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Fighting Arbovirus Transmission: Natural and Engineered Control of Vector Competence in Aedes Mosquitoes
Control of aedine mosquito vectors, either by mosquito population reduction or replacement with refractory mosquitoes, may play an essential role in the fight against arboviral diseases. In this review, we will focus on the development and application of biological approaches, both natural or engine...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553541/ https://www.ncbi.nlm.nih.gov/pubmed/26463078 http://dx.doi.org/10.3390/insects6010236 |
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author | Kean, Joy Rainey, Stephanie M. McFarlane, Melanie Donald, Claire L. Schnettler, Esther Kohl, Alain Pondeville, Emilie |
author_facet | Kean, Joy Rainey, Stephanie M. McFarlane, Melanie Donald, Claire L. Schnettler, Esther Kohl, Alain Pondeville, Emilie |
author_sort | Kean, Joy |
collection | PubMed |
description | Control of aedine mosquito vectors, either by mosquito population reduction or replacement with refractory mosquitoes, may play an essential role in the fight against arboviral diseases. In this review, we will focus on the development and application of biological approaches, both natural or engineered, to limit mosquito vector competence for arboviruses. The study of mosquito antiviral immunity has led to the identification of a number of host response mechanisms and proteins that are required to control arbovirus replication in mosquitoes, though more factors influencing vector competence are likely to be discovered. We will discuss key aspects of these pathways as targets either for selection of naturally resistant mosquito populations or for mosquito genetic manipulation. Moreover, we will consider the use of endosymbiotic bacteria such as Wolbachia, which in some cases have proven to be remarkably efficient in disrupting arbovirus transmission by mosquitoes, but also the use of naturally occurring insect-specific viruses that may interfere with arboviruses in mosquito vectors. Finally, we will discuss the use of paratransgenesis as well as entomopathogenic fungi, which are also proposed strategies to control vector competence. |
format | Online Article Text |
id | pubmed-4553541 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-45535412015-10-08 Fighting Arbovirus Transmission: Natural and Engineered Control of Vector Competence in Aedes Mosquitoes Kean, Joy Rainey, Stephanie M. McFarlane, Melanie Donald, Claire L. Schnettler, Esther Kohl, Alain Pondeville, Emilie Insects Review Control of aedine mosquito vectors, either by mosquito population reduction or replacement with refractory mosquitoes, may play an essential role in the fight against arboviral diseases. In this review, we will focus on the development and application of biological approaches, both natural or engineered, to limit mosquito vector competence for arboviruses. The study of mosquito antiviral immunity has led to the identification of a number of host response mechanisms and proteins that are required to control arbovirus replication in mosquitoes, though more factors influencing vector competence are likely to be discovered. We will discuss key aspects of these pathways as targets either for selection of naturally resistant mosquito populations or for mosquito genetic manipulation. Moreover, we will consider the use of endosymbiotic bacteria such as Wolbachia, which in some cases have proven to be remarkably efficient in disrupting arbovirus transmission by mosquitoes, but also the use of naturally occurring insect-specific viruses that may interfere with arboviruses in mosquito vectors. Finally, we will discuss the use of paratransgenesis as well as entomopathogenic fungi, which are also proposed strategies to control vector competence. MDPI 2015-03-23 /pmc/articles/PMC4553541/ /pubmed/26463078 http://dx.doi.org/10.3390/insects6010236 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kean, Joy Rainey, Stephanie M. McFarlane, Melanie Donald, Claire L. Schnettler, Esther Kohl, Alain Pondeville, Emilie Fighting Arbovirus Transmission: Natural and Engineered Control of Vector Competence in Aedes Mosquitoes |
title | Fighting Arbovirus Transmission: Natural and Engineered Control of Vector Competence in Aedes Mosquitoes |
title_full | Fighting Arbovirus Transmission: Natural and Engineered Control of Vector Competence in Aedes Mosquitoes |
title_fullStr | Fighting Arbovirus Transmission: Natural and Engineered Control of Vector Competence in Aedes Mosquitoes |
title_full_unstemmed | Fighting Arbovirus Transmission: Natural and Engineered Control of Vector Competence in Aedes Mosquitoes |
title_short | Fighting Arbovirus Transmission: Natural and Engineered Control of Vector Competence in Aedes Mosquitoes |
title_sort | fighting arbovirus transmission: natural and engineered control of vector competence in aedes mosquitoes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553541/ https://www.ncbi.nlm.nih.gov/pubmed/26463078 http://dx.doi.org/10.3390/insects6010236 |
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