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Long-Term Risk of Acute Coronary Syndrome in Splenectomized Patients Due to Splenic Injury
We aimed to assess the magnitude and duration of risk of acute coronary syndrome (ACS) associated with splenectomy for splenic injury. We identified 5139 splenectomized patients (the splenectomy cohort) to compare with 2 other cohorts for assessing the magnitude and risk of ACS: the first cohort com...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553951/ https://www.ncbi.nlm.nih.gov/pubmed/25738485 http://dx.doi.org/10.1097/MD.0000000000000610 |
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author | Tsai, Ming-Shian Chou, Sheng-En Lai, Hong-Shiee Jeng, Long-Bin Lin, Cheng-Li Kao, Chia-Hung |
author_facet | Tsai, Ming-Shian Chou, Sheng-En Lai, Hong-Shiee Jeng, Long-Bin Lin, Cheng-Li Kao, Chia-Hung |
author_sort | Tsai, Ming-Shian |
collection | PubMed |
description | We aimed to assess the magnitude and duration of risk of acute coronary syndrome (ACS) associated with splenectomy for splenic injury. We identified 5139 splenectomized patients (the splenectomy cohort) to compare with 2 other cohorts for assessing the magnitude and risk of ACS: the first cohort comprising subjects without splenic injury and without splenectomy (control cohort), and the second cohort comprising nonsplenectomized patients with splenic injury (nonsplenectomy cohort; n = 6391). For each splenic injury patient (n = 11530), 4 control comparisons were frequency-matched by the year of index date, age, and sex (n = 46120). The adjusted risk of ACS was significantly higher in the splenectomy group than in the control group (2.08 vs 1.68 per 1000 person-years; adjusted hazard ratio [HR], 1.30; 95% confidence interval [CI], 1.01–1.68). The sex-specific data showed that the adjusted HR for the splenectomy group, compared with the control group, was 1.29 in men (95% CI, 0.97–1.73) and 1.36 in women (95% CI, 0.79–2.33). The age-specific analyses failed to demonstrate a significantly higher adjusted HR of ACS in the splenectomized patients in any age subgroup, compared with their counterparts in the control group. Furthermore, no difference in the risk of ACS was detected between the splenectomy and nonsplenectomy cohorts within the splenic injury patients. In comparison with the control cohort, patients undergoing splenectomy for splenic injury exhibited an elevated risk of ACS. |
format | Online Article Text |
id | pubmed-4553951 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-45539512015-10-27 Long-Term Risk of Acute Coronary Syndrome in Splenectomized Patients Due to Splenic Injury Tsai, Ming-Shian Chou, Sheng-En Lai, Hong-Shiee Jeng, Long-Bin Lin, Cheng-Li Kao, Chia-Hung Medicine (Baltimore) 7100 We aimed to assess the magnitude and duration of risk of acute coronary syndrome (ACS) associated with splenectomy for splenic injury. We identified 5139 splenectomized patients (the splenectomy cohort) to compare with 2 other cohorts for assessing the magnitude and risk of ACS: the first cohort comprising subjects without splenic injury and without splenectomy (control cohort), and the second cohort comprising nonsplenectomized patients with splenic injury (nonsplenectomy cohort; n = 6391). For each splenic injury patient (n = 11530), 4 control comparisons were frequency-matched by the year of index date, age, and sex (n = 46120). The adjusted risk of ACS was significantly higher in the splenectomy group than in the control group (2.08 vs 1.68 per 1000 person-years; adjusted hazard ratio [HR], 1.30; 95% confidence interval [CI], 1.01–1.68). The sex-specific data showed that the adjusted HR for the splenectomy group, compared with the control group, was 1.29 in men (95% CI, 0.97–1.73) and 1.36 in women (95% CI, 0.79–2.33). The age-specific analyses failed to demonstrate a significantly higher adjusted HR of ACS in the splenectomized patients in any age subgroup, compared with their counterparts in the control group. Furthermore, no difference in the risk of ACS was detected between the splenectomy and nonsplenectomy cohorts within the splenic injury patients. In comparison with the control cohort, patients undergoing splenectomy for splenic injury exhibited an elevated risk of ACS. Wolters Kluwer Health 2015-03-06 /pmc/articles/PMC4553951/ /pubmed/25738485 http://dx.doi.org/10.1097/MD.0000000000000610 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0 |
spellingShingle | 7100 Tsai, Ming-Shian Chou, Sheng-En Lai, Hong-Shiee Jeng, Long-Bin Lin, Cheng-Li Kao, Chia-Hung Long-Term Risk of Acute Coronary Syndrome in Splenectomized Patients Due to Splenic Injury |
title | Long-Term Risk of Acute Coronary Syndrome in Splenectomized Patients Due to Splenic Injury |
title_full | Long-Term Risk of Acute Coronary Syndrome in Splenectomized Patients Due to Splenic Injury |
title_fullStr | Long-Term Risk of Acute Coronary Syndrome in Splenectomized Patients Due to Splenic Injury |
title_full_unstemmed | Long-Term Risk of Acute Coronary Syndrome in Splenectomized Patients Due to Splenic Injury |
title_short | Long-Term Risk of Acute Coronary Syndrome in Splenectomized Patients Due to Splenic Injury |
title_sort | long-term risk of acute coronary syndrome in splenectomized patients due to splenic injury |
topic | 7100 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553951/ https://www.ncbi.nlm.nih.gov/pubmed/25738485 http://dx.doi.org/10.1097/MD.0000000000000610 |
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