Cargando…

Increased Cerebellar-Default-Mode-Network Connectivity in Drug-Naive Major Depressive Disorder at Rest

The default-mode network (DMN) has been implicated in the neurobiology of major depressive disorder (MDD), and the cerebellum is suggested to be involved in high-order cognitive network such as the DMN. However, the specific contribution of the cerebellum to the DMN alterations remains equivocal. Th...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Wenbin, Liu, Feng, Liu, Jianrong, Yu, Miaoyu, Zhang, Zhikun, Liu, Guiying, Xiao, Changqing, Zhao, Jingping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553960/
https://www.ncbi.nlm.nih.gov/pubmed/25738471
http://dx.doi.org/10.1097/MD.0000000000000560
_version_ 1782387982218559488
author Guo, Wenbin
Liu, Feng
Liu, Jianrong
Yu, Miaoyu
Zhang, Zhikun
Liu, Guiying
Xiao, Changqing
Zhao, Jingping
author_facet Guo, Wenbin
Liu, Feng
Liu, Jianrong
Yu, Miaoyu
Zhang, Zhikun
Liu, Guiying
Xiao, Changqing
Zhao, Jingping
author_sort Guo, Wenbin
collection PubMed
description The default-mode network (DMN) has been implicated in the neurobiology of major depressive disorder (MDD), and the cerebellum is suggested to be involved in high-order cognitive network such as the DMN. However, the specific contribution of the cerebellum to the DMN alterations remains equivocal. This study was conducted to examine the cerebellar-DMN connectivity in drug-naive MDD directly by using the cerebellum Crus I as seeds. Forty-four drug-naive MDD patients and 44 healthy controls participated in the resting-state scan. Functional connectivity (FC) was applied to analyze the images. Significantly increased FCs were observed between the right Crus I and the right inferior frontal cortex (orbital part)/superior temporal pole, bilateral MPFC (orbital part), and left middle temporal gyrus in the patients compared with the controls. There was a significantly positive correlation between the z values of the right Crus I–bilateral MPFC (orbital part) connectivity and the scores of Automatic Thoughts Questionnaire in the patients (r = 0.329, P = 0.029). The findings reveal that depressed patients have increased cerebellar-DMN connectivity with clinical significance, and thus highlight the contribution of the cerebellum to the DMN alterations in neurobiology of MDD.
format Online
Article
Text
id pubmed-4553960
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-45539602015-10-27 Increased Cerebellar-Default-Mode-Network Connectivity in Drug-Naive Major Depressive Disorder at Rest Guo, Wenbin Liu, Feng Liu, Jianrong Yu, Miaoyu Zhang, Zhikun Liu, Guiying Xiao, Changqing Zhao, Jingping Medicine (Baltimore) 5000 The default-mode network (DMN) has been implicated in the neurobiology of major depressive disorder (MDD), and the cerebellum is suggested to be involved in high-order cognitive network such as the DMN. However, the specific contribution of the cerebellum to the DMN alterations remains equivocal. This study was conducted to examine the cerebellar-DMN connectivity in drug-naive MDD directly by using the cerebellum Crus I as seeds. Forty-four drug-naive MDD patients and 44 healthy controls participated in the resting-state scan. Functional connectivity (FC) was applied to analyze the images. Significantly increased FCs were observed between the right Crus I and the right inferior frontal cortex (orbital part)/superior temporal pole, bilateral MPFC (orbital part), and left middle temporal gyrus in the patients compared with the controls. There was a significantly positive correlation between the z values of the right Crus I–bilateral MPFC (orbital part) connectivity and the scores of Automatic Thoughts Questionnaire in the patients (r = 0.329, P = 0.029). The findings reveal that depressed patients have increased cerebellar-DMN connectivity with clinical significance, and thus highlight the contribution of the cerebellum to the DMN alterations in neurobiology of MDD. Wolters Kluwer Health 2015-03-06 /pmc/articles/PMC4553960/ /pubmed/25738471 http://dx.doi.org/10.1097/MD.0000000000000560 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 5000
Guo, Wenbin
Liu, Feng
Liu, Jianrong
Yu, Miaoyu
Zhang, Zhikun
Liu, Guiying
Xiao, Changqing
Zhao, Jingping
Increased Cerebellar-Default-Mode-Network Connectivity in Drug-Naive Major Depressive Disorder at Rest
title Increased Cerebellar-Default-Mode-Network Connectivity in Drug-Naive Major Depressive Disorder at Rest
title_full Increased Cerebellar-Default-Mode-Network Connectivity in Drug-Naive Major Depressive Disorder at Rest
title_fullStr Increased Cerebellar-Default-Mode-Network Connectivity in Drug-Naive Major Depressive Disorder at Rest
title_full_unstemmed Increased Cerebellar-Default-Mode-Network Connectivity in Drug-Naive Major Depressive Disorder at Rest
title_short Increased Cerebellar-Default-Mode-Network Connectivity in Drug-Naive Major Depressive Disorder at Rest
title_sort increased cerebellar-default-mode-network connectivity in drug-naive major depressive disorder at rest
topic 5000
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553960/
https://www.ncbi.nlm.nih.gov/pubmed/25738471
http://dx.doi.org/10.1097/MD.0000000000000560
work_keys_str_mv AT guowenbin increasedcerebellardefaultmodenetworkconnectivityindrugnaivemajordepressivedisorderatrest
AT liufeng increasedcerebellardefaultmodenetworkconnectivityindrugnaivemajordepressivedisorderatrest
AT liujianrong increasedcerebellardefaultmodenetworkconnectivityindrugnaivemajordepressivedisorderatrest
AT yumiaoyu increasedcerebellardefaultmodenetworkconnectivityindrugnaivemajordepressivedisorderatrest
AT zhangzhikun increasedcerebellardefaultmodenetworkconnectivityindrugnaivemajordepressivedisorderatrest
AT liuguiying increasedcerebellardefaultmodenetworkconnectivityindrugnaivemajordepressivedisorderatrest
AT xiaochangqing increasedcerebellardefaultmodenetworkconnectivityindrugnaivemajordepressivedisorderatrest
AT zhaojingping increasedcerebellardefaultmodenetworkconnectivityindrugnaivemajordepressivedisorderatrest