Severe Cholestatic Hepatitis due to Temozolomide: An Adverse Drug Effect to Keep in Mind. Case Report and Review of Literature

Temozolomide is the current standard of therapy for postoperative patients with glioblastoma starting adjuvant radiotherapy. Hematologic adverse events are the most frequent side effects of temozolomide, while liver toxicity has been reported only in the post-marketing period. Here we report a case...

Descripción completa

Detalles Bibliográficos
Autores principales: Grieco, Antonio, Tafuri, Maria Antonietta, Biolato, Marco, Diletto, Barbara, Di Napoli, Nicola, Balducci, Nicola, Vecchio, Fabio Maria, Miele, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
4500
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554001/
https://www.ncbi.nlm.nih.gov/pubmed/25816026
http://dx.doi.org/10.1097/MD.0000000000000476
_version_ 1782387989935030272
author Grieco, Antonio
Tafuri, Maria Antonietta
Biolato, Marco
Diletto, Barbara
Di Napoli, Nicola
Balducci, Nicola
Vecchio, Fabio Maria
Miele, Luca
author_facet Grieco, Antonio
Tafuri, Maria Antonietta
Biolato, Marco
Diletto, Barbara
Di Napoli, Nicola
Balducci, Nicola
Vecchio, Fabio Maria
Miele, Luca
author_sort Grieco, Antonio
collection PubMed
description Temozolomide is the current standard of therapy for postoperative patients with glioblastoma starting adjuvant radiotherapy. Hematologic adverse events are the most frequent side effects of temozolomide, while liver toxicity has been reported only in the post-marketing period. Here we report a case of severe temozolomide-induced liver injury during concurrent radiotherapy treatment, at a dose level of 75 mg/m(2). The aim of this case report is to focus on the problems of temozolomide-induced hepatotoxicity. In conclusion, a close monitoring of liver function tests is recommended during treatment with temozolomide.
format Online
Article
Text
id pubmed-4554001
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-45540012015-10-27 Severe Cholestatic Hepatitis due to Temozolomide: An Adverse Drug Effect to Keep in Mind. Case Report and Review of Literature Grieco, Antonio Tafuri, Maria Antonietta Biolato, Marco Diletto, Barbara Di Napoli, Nicola Balducci, Nicola Vecchio, Fabio Maria Miele, Luca Medicine (Baltimore) 4500 Temozolomide is the current standard of therapy for postoperative patients with glioblastoma starting adjuvant radiotherapy. Hematologic adverse events are the most frequent side effects of temozolomide, while liver toxicity has been reported only in the post-marketing period. Here we report a case of severe temozolomide-induced liver injury during concurrent radiotherapy treatment, at a dose level of 75 mg/m(2). The aim of this case report is to focus on the problems of temozolomide-induced hepatotoxicity. In conclusion, a close monitoring of liver function tests is recommended during treatment with temozolomide. Wolters Kluwer Health 2015-03-27 /pmc/articles/PMC4554001/ /pubmed/25816026 http://dx.doi.org/10.1097/MD.0000000000000476 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 4500
Grieco, Antonio
Tafuri, Maria Antonietta
Biolato, Marco
Diletto, Barbara
Di Napoli, Nicola
Balducci, Nicola
Vecchio, Fabio Maria
Miele, Luca
Severe Cholestatic Hepatitis due to Temozolomide: An Adverse Drug Effect to Keep in Mind. Case Report and Review of Literature
title Severe Cholestatic Hepatitis due to Temozolomide: An Adverse Drug Effect to Keep in Mind. Case Report and Review of Literature
title_full Severe Cholestatic Hepatitis due to Temozolomide: An Adverse Drug Effect to Keep in Mind. Case Report and Review of Literature
title_fullStr Severe Cholestatic Hepatitis due to Temozolomide: An Adverse Drug Effect to Keep in Mind. Case Report and Review of Literature
title_full_unstemmed Severe Cholestatic Hepatitis due to Temozolomide: An Adverse Drug Effect to Keep in Mind. Case Report and Review of Literature
title_short Severe Cholestatic Hepatitis due to Temozolomide: An Adverse Drug Effect to Keep in Mind. Case Report and Review of Literature
title_sort severe cholestatic hepatitis due to temozolomide: an adverse drug effect to keep in mind. case report and review of literature
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554001/
https://www.ncbi.nlm.nih.gov/pubmed/25816026
http://dx.doi.org/10.1097/MD.0000000000000476
work_keys_str_mv AT griecoantonio severecholestatichepatitisduetotemozolomideanadversedrugeffecttokeepinmindcasereportandreviewofliterature
AT tafurimariaantonietta severecholestatichepatitisduetotemozolomideanadversedrugeffecttokeepinmindcasereportandreviewofliterature
AT biolatomarco severecholestatichepatitisduetotemozolomideanadversedrugeffecttokeepinmindcasereportandreviewofliterature
AT dilettobarbara severecholestatichepatitisduetotemozolomideanadversedrugeffecttokeepinmindcasereportandreviewofliterature
AT dinapolinicola severecholestatichepatitisduetotemozolomideanadversedrugeffecttokeepinmindcasereportandreviewofliterature
AT balduccinicola severecholestatichepatitisduetotemozolomideanadversedrugeffecttokeepinmindcasereportandreviewofliterature
AT vecchiofabiomaria severecholestatichepatitisduetotemozolomideanadversedrugeffecttokeepinmindcasereportandreviewofliterature
AT mieleluca severecholestatichepatitisduetotemozolomideanadversedrugeffecttokeepinmindcasereportandreviewofliterature

Ejemplares similares