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Differential Expression of Hypertension-Associated MicroRNAs in the Plasma of Patients With White Coat Hypertension

White coat hypertension (WCH) is a high cardiovascular risk condition, and a fundamental understanding of the cause and pathophysiology of the disorder is still lacking. Recent studies demonstrated that microRNAs (miRNAs) are involved in hypertension; however, the roles of miRNAs in WCH are not know...

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Autores principales: Cengiz, Mahir, Karatas, Omer Faruk, Koparir, Erkan, Yavuzer, Serap, Ali, Chayar, Yavuzer, Hakan, Kirat, Emre, Karter, Yesari, Ozen, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554020/
https://www.ncbi.nlm.nih.gov/pubmed/25837765
http://dx.doi.org/10.1097/MD.0000000000000693
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author Cengiz, Mahir
Karatas, Omer Faruk
Koparir, Erkan
Yavuzer, Serap
Ali, Chayar
Yavuzer, Hakan
Kirat, Emre
Karter, Yesari
Ozen, Mustafa
author_facet Cengiz, Mahir
Karatas, Omer Faruk
Koparir, Erkan
Yavuzer, Serap
Ali, Chayar
Yavuzer, Hakan
Kirat, Emre
Karter, Yesari
Ozen, Mustafa
author_sort Cengiz, Mahir
collection PubMed
description White coat hypertension (WCH) is a high cardiovascular risk condition, and a fundamental understanding of the cause and pathophysiology of the disorder is still lacking. Recent studies demonstrated that microRNAs (miRNAs) are involved in hypertension; however, the roles of miRNAs in WCH are not known. The expressions of selected 10 miRNAs were investigated independently in plasma samples from 30 hypertension (HT) patients, 30 WCH patients, and 30 normotensive (NT) subjects. MiR-21, miR-122, miR-637, and let-7e expression levels were significantly upregulated in the HT group compared with the NT groups (P = 0.017, P = 0.022, P = 0.048, and P = 0.013, respectively). MiR-122 and miR-637 expressions were also significantly upregulated in the WCH group compared with the NT group (P = 0.048 and P = 0.039, respectively). MiR-296-5p expression level was significantly downregulated in HT patients and upregulated in the WCH patients compared with the NT group (P = 0.049 and P = 0.039, respectively). Additionally, the ambulatory 24-hour and daytime systolic and diastolic blood pressures were negatively correlated with miR-296-5p. MiR-296 and miR-637 had area under the curve (AUC) values of 0.778 and 0.774, respectively, which demonstrates their sufficiency to distinguish WCH from NT individuals. MiR-296 and miR-637 had AUC values of 0.868 and 0.680, respectively, which shows their potential to distinguish WCH from HT individuals. We report for the first time a plasma miRNA profile for WCH patients and demonstrate a novel link between miRNA and WCH. These findings may reveal crucial insights into the development of WCH.
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spelling pubmed-45540202015-10-27 Differential Expression of Hypertension-Associated MicroRNAs in the Plasma of Patients With White Coat Hypertension Cengiz, Mahir Karatas, Omer Faruk Koparir, Erkan Yavuzer, Serap Ali, Chayar Yavuzer, Hakan Kirat, Emre Karter, Yesari Ozen, Mustafa Medicine (Baltimore) 3400 White coat hypertension (WCH) is a high cardiovascular risk condition, and a fundamental understanding of the cause and pathophysiology of the disorder is still lacking. Recent studies demonstrated that microRNAs (miRNAs) are involved in hypertension; however, the roles of miRNAs in WCH are not known. The expressions of selected 10 miRNAs were investigated independently in plasma samples from 30 hypertension (HT) patients, 30 WCH patients, and 30 normotensive (NT) subjects. MiR-21, miR-122, miR-637, and let-7e expression levels were significantly upregulated in the HT group compared with the NT groups (P = 0.017, P = 0.022, P = 0.048, and P = 0.013, respectively). MiR-122 and miR-637 expressions were also significantly upregulated in the WCH group compared with the NT group (P = 0.048 and P = 0.039, respectively). MiR-296-5p expression level was significantly downregulated in HT patients and upregulated in the WCH patients compared with the NT group (P = 0.049 and P = 0.039, respectively). Additionally, the ambulatory 24-hour and daytime systolic and diastolic blood pressures were negatively correlated with miR-296-5p. MiR-296 and miR-637 had area under the curve (AUC) values of 0.778 and 0.774, respectively, which demonstrates their sufficiency to distinguish WCH from NT individuals. MiR-296 and miR-637 had AUC values of 0.868 and 0.680, respectively, which shows their potential to distinguish WCH from HT individuals. We report for the first time a plasma miRNA profile for WCH patients and demonstrate a novel link between miRNA and WCH. These findings may reveal crucial insights into the development of WCH. Wolters Kluwer Health 2015-04-03 /pmc/articles/PMC4554020/ /pubmed/25837765 http://dx.doi.org/10.1097/MD.0000000000000693 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 3400
Cengiz, Mahir
Karatas, Omer Faruk
Koparir, Erkan
Yavuzer, Serap
Ali, Chayar
Yavuzer, Hakan
Kirat, Emre
Karter, Yesari
Ozen, Mustafa
Differential Expression of Hypertension-Associated MicroRNAs in the Plasma of Patients With White Coat Hypertension
title Differential Expression of Hypertension-Associated MicroRNAs in the Plasma of Patients With White Coat Hypertension
title_full Differential Expression of Hypertension-Associated MicroRNAs in the Plasma of Patients With White Coat Hypertension
title_fullStr Differential Expression of Hypertension-Associated MicroRNAs in the Plasma of Patients With White Coat Hypertension
title_full_unstemmed Differential Expression of Hypertension-Associated MicroRNAs in the Plasma of Patients With White Coat Hypertension
title_short Differential Expression of Hypertension-Associated MicroRNAs in the Plasma of Patients With White Coat Hypertension
title_sort differential expression of hypertension-associated micrornas in the plasma of patients with white coat hypertension
topic 3400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554020/
https://www.ncbi.nlm.nih.gov/pubmed/25837765
http://dx.doi.org/10.1097/MD.0000000000000693
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