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Assessment of Risk for Recurrent Diverticulitis: A Proposal of Risk Score for Complicated Recurrence

Recurrence of acute diverticulitis is common, and—especially complicated recurrence—causes significant morbidity. To prevent recurrence, selected patients have been offered prophylactic sigmoid resection. However, as there is no tool to predict whose diverticulitis will recur and, in particular, who...

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Autores principales: Sallinen, Ville, Mali, Juha, Leppäniemi, Ari, Mentula, Panu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554145/
https://www.ncbi.nlm.nih.gov/pubmed/25715253
http://dx.doi.org/10.1097/MD.0000000000000557
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author Sallinen, Ville
Mali, Juha
Leppäniemi, Ari
Mentula, Panu
author_facet Sallinen, Ville
Mali, Juha
Leppäniemi, Ari
Mentula, Panu
author_sort Sallinen, Ville
collection PubMed
description Recurrence of acute diverticulitis is common, and—especially complicated recurrence—causes significant morbidity. To prevent recurrence, selected patients have been offered prophylactic sigmoid resection. However, as there is no tool to predict whose diverticulitis will recur and, in particular, who will have complicated recurrence, the indications for sigmoid resections have been variable. The objective of this study was to identify risk factors predicting recurrence of acute diverticulitis. This is a retrospective cohort study of patients presenting with computed tomography–confirmed acute diverticulitis and treated nonresectionally during 2006 to 2010. Risk factors for recurrence were identified using uni- and multivariate Cox regression. A total of 512 patients were included. History of diverticulitis was an independent risk factor predicting uncomplicated recurrence of diverticulitis (1–2 earlier diverticulitis HR 1.6, 3 or more—HR 3.2). History of diverticulitis (HR 3.3), abscess (HR 6.2), and corticosteroid medication (HR 16.1) were independent risk factors for complicated recurrence. Based on regression coefficients, risk scoring was created: 1 point for history of diverticulitis, 2 points for abscess, and 3 points for corticosteroid medication. The risk score was unable to predict uncomplicated recurrence (AUC 0.48), but was able to predict complicated recurrence (AUC 0.80). Patients were further divided into low-risk (0–2 points) and high-risk (>2 points) groups. Low-risk and high-risk groups had 3% and 43% 5-year complicated recurrence rates, respectively. Risk for complicated recurrence of acute diverticulitis can be assessed using risk scoring. The risk for uncomplicated recurrence increases along with increasing number of previous diverticulitis.
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spelling pubmed-45541452015-10-27 Assessment of Risk for Recurrent Diverticulitis: A Proposal of Risk Score for Complicated Recurrence Sallinen, Ville Mali, Juha Leppäniemi, Ari Mentula, Panu Medicine (Baltimore) 4500 Recurrence of acute diverticulitis is common, and—especially complicated recurrence—causes significant morbidity. To prevent recurrence, selected patients have been offered prophylactic sigmoid resection. However, as there is no tool to predict whose diverticulitis will recur and, in particular, who will have complicated recurrence, the indications for sigmoid resections have been variable. The objective of this study was to identify risk factors predicting recurrence of acute diverticulitis. This is a retrospective cohort study of patients presenting with computed tomography–confirmed acute diverticulitis and treated nonresectionally during 2006 to 2010. Risk factors for recurrence were identified using uni- and multivariate Cox regression. A total of 512 patients were included. History of diverticulitis was an independent risk factor predicting uncomplicated recurrence of diverticulitis (1–2 earlier diverticulitis HR 1.6, 3 or more—HR 3.2). History of diverticulitis (HR 3.3), abscess (HR 6.2), and corticosteroid medication (HR 16.1) were independent risk factors for complicated recurrence. Based on regression coefficients, risk scoring was created: 1 point for history of diverticulitis, 2 points for abscess, and 3 points for corticosteroid medication. The risk score was unable to predict uncomplicated recurrence (AUC 0.48), but was able to predict complicated recurrence (AUC 0.80). Patients were further divided into low-risk (0–2 points) and high-risk (>2 points) groups. Low-risk and high-risk groups had 3% and 43% 5-year complicated recurrence rates, respectively. Risk for complicated recurrence of acute diverticulitis can be assessed using risk scoring. The risk for uncomplicated recurrence increases along with increasing number of previous diverticulitis. Wolters Kluwer Health 2015-02-27 /pmc/articles/PMC4554145/ /pubmed/25715253 http://dx.doi.org/10.1097/MD.0000000000000557 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 4500
Sallinen, Ville
Mali, Juha
Leppäniemi, Ari
Mentula, Panu
Assessment of Risk for Recurrent Diverticulitis: A Proposal of Risk Score for Complicated Recurrence
title Assessment of Risk for Recurrent Diverticulitis: A Proposal of Risk Score for Complicated Recurrence
title_full Assessment of Risk for Recurrent Diverticulitis: A Proposal of Risk Score for Complicated Recurrence
title_fullStr Assessment of Risk for Recurrent Diverticulitis: A Proposal of Risk Score for Complicated Recurrence
title_full_unstemmed Assessment of Risk for Recurrent Diverticulitis: A Proposal of Risk Score for Complicated Recurrence
title_short Assessment of Risk for Recurrent Diverticulitis: A Proposal of Risk Score for Complicated Recurrence
title_sort assessment of risk for recurrent diverticulitis: a proposal of risk score for complicated recurrence
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554145/
https://www.ncbi.nlm.nih.gov/pubmed/25715253
http://dx.doi.org/10.1097/MD.0000000000000557
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