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Comparison of Intranasal and Intravenous Diazepam on Status Epilepticus in Stroke Patients: A Retrospective Cohort Study

Administering diazepam intravenously or rectally in an adult with status epilepticus can be difficult and time consuming. The aim of this study was to examine whether intranasal diazepam is an effective alternative to intravenous diazepam when treating status epilepticus. We undertook a retrospectiv...

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Autores principales: Inokuchi, Ryota, Ohashi-Fukuda, Naoko, Nakamura, Kensuke, Wada, Tomoki, Gunshin, Masataka, Kitsuta, Yoichi, Nakajima, Susumu, Yahagi, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554181/
https://www.ncbi.nlm.nih.gov/pubmed/25700327
http://dx.doi.org/10.1097/MD.0000000000000555
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author Inokuchi, Ryota
Ohashi-Fukuda, Naoko
Nakamura, Kensuke
Wada, Tomoki
Gunshin, Masataka
Kitsuta, Yoichi
Nakajima, Susumu
Yahagi, Naoki
author_facet Inokuchi, Ryota
Ohashi-Fukuda, Naoko
Nakamura, Kensuke
Wada, Tomoki
Gunshin, Masataka
Kitsuta, Yoichi
Nakajima, Susumu
Yahagi, Naoki
author_sort Inokuchi, Ryota
collection PubMed
description Administering diazepam intravenously or rectally in an adult with status epilepticus can be difficult and time consuming. The aim of this study was to examine whether intranasal diazepam is an effective alternative to intravenous diazepam when treating status epilepticus. We undertook a retrospective cohort study based on the medical records of 19 stroke patients presenting with status epilepticus to our institution. We measured the time between arrival at the hospital, the intravenous or intranasal administration of diazepam, and the seizure termination. Intranasal diazepam was administered about 9 times faster than intravenous diazepam (1 vs 9.5 minutes, P = 0.001), resulting in about 3-fold reduction in the time to termination of seizure activity after arrival at the hospital (3 minutes compared with 9.5 minutes in the intravenous group, P = 0.030). No adverse effects of intranasal diazepam were evident from the medical records. Intranasal diazepam administration is safer, easier, and quicker than intravenous administration.
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spelling pubmed-45541812015-10-27 Comparison of Intranasal and Intravenous Diazepam on Status Epilepticus in Stroke Patients: A Retrospective Cohort Study Inokuchi, Ryota Ohashi-Fukuda, Naoko Nakamura, Kensuke Wada, Tomoki Gunshin, Masataka Kitsuta, Yoichi Nakajima, Susumu Yahagi, Naoki Medicine (Baltimore) 3900 Administering diazepam intravenously or rectally in an adult with status epilepticus can be difficult and time consuming. The aim of this study was to examine whether intranasal diazepam is an effective alternative to intravenous diazepam when treating status epilepticus. We undertook a retrospective cohort study based on the medical records of 19 stroke patients presenting with status epilepticus to our institution. We measured the time between arrival at the hospital, the intravenous or intranasal administration of diazepam, and the seizure termination. Intranasal diazepam was administered about 9 times faster than intravenous diazepam (1 vs 9.5 minutes, P = 0.001), resulting in about 3-fold reduction in the time to termination of seizure activity after arrival at the hospital (3 minutes compared with 9.5 minutes in the intravenous group, P = 0.030). No adverse effects of intranasal diazepam were evident from the medical records. Intranasal diazepam administration is safer, easier, and quicker than intravenous administration. Wolters Kluwer Health 2015-02-20 /pmc/articles/PMC4554181/ /pubmed/25700327 http://dx.doi.org/10.1097/MD.0000000000000555 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 3900
Inokuchi, Ryota
Ohashi-Fukuda, Naoko
Nakamura, Kensuke
Wada, Tomoki
Gunshin, Masataka
Kitsuta, Yoichi
Nakajima, Susumu
Yahagi, Naoki
Comparison of Intranasal and Intravenous Diazepam on Status Epilepticus in Stroke Patients: A Retrospective Cohort Study
title Comparison of Intranasal and Intravenous Diazepam on Status Epilepticus in Stroke Patients: A Retrospective Cohort Study
title_full Comparison of Intranasal and Intravenous Diazepam on Status Epilepticus in Stroke Patients: A Retrospective Cohort Study
title_fullStr Comparison of Intranasal and Intravenous Diazepam on Status Epilepticus in Stroke Patients: A Retrospective Cohort Study
title_full_unstemmed Comparison of Intranasal and Intravenous Diazepam on Status Epilepticus in Stroke Patients: A Retrospective Cohort Study
title_short Comparison of Intranasal and Intravenous Diazepam on Status Epilepticus in Stroke Patients: A Retrospective Cohort Study
title_sort comparison of intranasal and intravenous diazepam on status epilepticus in stroke patients: a retrospective cohort study
topic 3900
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554181/
https://www.ncbi.nlm.nih.gov/pubmed/25700327
http://dx.doi.org/10.1097/MD.0000000000000555
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