BCR-ABL Mutation-Guided Therapy for CML Blast Crisis: A Case Report

The management of patients with chronic myeloid leukemia (CML) in advanced phases is challenging and requires the consideration of different treatment approaches, including targeted therapy with tyrosine kinase inhibitors, cytotoxic chemotherapy, and allogeneic stem cell transplantation. Here, we pr...

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Detalles Bibliográficos
Autores principales: Ostendorf, Benjamin N, Nogai, Hendrik, Baldus, Claudia D, Burmeister, Thomas, Arnold, Renate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554357/
https://www.ncbi.nlm.nih.gov/pubmed/26379418
http://dx.doi.org/10.4137/BMI.S22279
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author Ostendorf, Benjamin N
Nogai, Hendrik
Baldus, Claudia D
Burmeister, Thomas
Arnold, Renate
author_facet Ostendorf, Benjamin N
Nogai, Hendrik
Baldus, Claudia D
Burmeister, Thomas
Arnold, Renate
author_sort Ostendorf, Benjamin N
collection PubMed
description The management of patients with chronic myeloid leukemia (CML) in advanced phases is challenging and requires the consideration of different treatment approaches, including targeted therapy with tyrosine kinase inhibitors, cytotoxic chemotherapy, and allogeneic stem cell transplantation. Here, we present the case of a patient with CML in mixed phenotype blast phase illustrating the integration of these strategies and demonstrating the need for close monitoring of treatment response in order to individually adjust treatment regimens.
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spelling pubmed-45543572015-09-16 BCR-ABL Mutation-Guided Therapy for CML Blast Crisis: A Case Report Ostendorf, Benjamin N Nogai, Hendrik Baldus, Claudia D Burmeister, Thomas Arnold, Renate Biomark Insights Case Report The management of patients with chronic myeloid leukemia (CML) in advanced phases is challenging and requires the consideration of different treatment approaches, including targeted therapy with tyrosine kinase inhibitors, cytotoxic chemotherapy, and allogeneic stem cell transplantation. Here, we present the case of a patient with CML in mixed phenotype blast phase illustrating the integration of these strategies and demonstrating the need for close monitoring of treatment response in order to individually adjust treatment regimens. Libertas Academica 2015-08-30 /pmc/articles/PMC4554357/ /pubmed/26379418 http://dx.doi.org/10.4137/BMI.S22279 Text en © 2015 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Case Report
Ostendorf, Benjamin N
Nogai, Hendrik
Baldus, Claudia D
Burmeister, Thomas
Arnold, Renate
BCR-ABL Mutation-Guided Therapy for CML Blast Crisis: A Case Report
title BCR-ABL Mutation-Guided Therapy for CML Blast Crisis: A Case Report
title_full BCR-ABL Mutation-Guided Therapy for CML Blast Crisis: A Case Report
title_fullStr BCR-ABL Mutation-Guided Therapy for CML Blast Crisis: A Case Report
title_full_unstemmed BCR-ABL Mutation-Guided Therapy for CML Blast Crisis: A Case Report
title_short BCR-ABL Mutation-Guided Therapy for CML Blast Crisis: A Case Report
title_sort bcr-abl mutation-guided therapy for cml blast crisis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554357/
https://www.ncbi.nlm.nih.gov/pubmed/26379418
http://dx.doi.org/10.4137/BMI.S22279
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AT burmeisterthomas bcrablmutationguidedtherapyforcmlblastcrisisacasereport
AT arnoldrenate bcrablmutationguidedtherapyforcmlblastcrisisacasereport

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