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Expression of EGFR Is Closely Related to Reduced 3-Year Survival Rate in Chinese Female NSCLC
BACKGROUND: Non-small cell lung cancer (NSCLC) accounts for approximately 80% of lung carcinoma cases, which becomes more and more important in the field of lung carcinoma as well as primary lung carcinoma in females. MATERIAL/METHODS: We analyzed the medical history of 62 female NSCLC patients. Imm...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554359/ https://www.ncbi.nlm.nih.gov/pubmed/26230859 http://dx.doi.org/10.12659/MSM.894786 |
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author | Sun, Guangyuan Liu, Bing He, Jin Zhao, Xuewei Li, Bing |
author_facet | Sun, Guangyuan Liu, Bing He, Jin Zhao, Xuewei Li, Bing |
author_sort | Sun, Guangyuan |
collection | PubMed |
description | BACKGROUND: Non-small cell lung cancer (NSCLC) accounts for approximately 80% of lung carcinoma cases, which becomes more and more important in the field of lung carcinoma as well as primary lung carcinoma in females. MATERIAL/METHODS: We analyzed the medical history of 62 female NSCLC patients. Immunohistochemistry was used to observe and compare the expression of EGFR. The chi-square test was conducted to analyze associations between EGFR expression and the different variables. The cumulative survival rate was determined by the Kaplan-Meier product-limit method. The prognosis of female patients with NSCLC was examined by using a multivariate Cox proportional hazard regression model. RESULTS: The expression proportion of EGFR in Chinese female NSCLC patients was 70.97%, and it was remarkably higher in adenocarcinoma than in squamous cell carcinoma and bronchioloalveolar carcinoma. A positive correlation was observed between EGFR expression and tumor-node metastasis staging or lymph node metastasis. The Cox proportional risk model analysis showed a correlation between postoperative survival time of the patients and pathology of the tumor type and lymph node metastasis. CONCLUSIONS: Expression of EGFR was closely related to pathology of the tumor type, tumor-node metastasis staging, and lymph node metastasis, which could be used as a promising indicator of NSCLC in Chinese female patients. |
format | Online Article Text |
id | pubmed-4554359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-45543592015-09-15 Expression of EGFR Is Closely Related to Reduced 3-Year Survival Rate in Chinese Female NSCLC Sun, Guangyuan Liu, Bing He, Jin Zhao, Xuewei Li, Bing Med Sci Monit Clinical Research BACKGROUND: Non-small cell lung cancer (NSCLC) accounts for approximately 80% of lung carcinoma cases, which becomes more and more important in the field of lung carcinoma as well as primary lung carcinoma in females. MATERIAL/METHODS: We analyzed the medical history of 62 female NSCLC patients. Immunohistochemistry was used to observe and compare the expression of EGFR. The chi-square test was conducted to analyze associations between EGFR expression and the different variables. The cumulative survival rate was determined by the Kaplan-Meier product-limit method. The prognosis of female patients with NSCLC was examined by using a multivariate Cox proportional hazard regression model. RESULTS: The expression proportion of EGFR in Chinese female NSCLC patients was 70.97%, and it was remarkably higher in adenocarcinoma than in squamous cell carcinoma and bronchioloalveolar carcinoma. A positive correlation was observed between EGFR expression and tumor-node metastasis staging or lymph node metastasis. The Cox proportional risk model analysis showed a correlation between postoperative survival time of the patients and pathology of the tumor type and lymph node metastasis. CONCLUSIONS: Expression of EGFR was closely related to pathology of the tumor type, tumor-node metastasis staging, and lymph node metastasis, which could be used as a promising indicator of NSCLC in Chinese female patients. International Scientific Literature, Inc. 2015-07-31 /pmc/articles/PMC4554359/ /pubmed/26230859 http://dx.doi.org/10.12659/MSM.894786 Text en © Med Sci Monit, 2015 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License |
spellingShingle | Clinical Research Sun, Guangyuan Liu, Bing He, Jin Zhao, Xuewei Li, Bing Expression of EGFR Is Closely Related to Reduced 3-Year Survival Rate in Chinese Female NSCLC |
title | Expression of EGFR Is Closely Related to Reduced 3-Year Survival Rate in Chinese Female NSCLC |
title_full | Expression of EGFR Is Closely Related to Reduced 3-Year Survival Rate in Chinese Female NSCLC |
title_fullStr | Expression of EGFR Is Closely Related to Reduced 3-Year Survival Rate in Chinese Female NSCLC |
title_full_unstemmed | Expression of EGFR Is Closely Related to Reduced 3-Year Survival Rate in Chinese Female NSCLC |
title_short | Expression of EGFR Is Closely Related to Reduced 3-Year Survival Rate in Chinese Female NSCLC |
title_sort | expression of egfr is closely related to reduced 3-year survival rate in chinese female nsclc |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554359/ https://www.ncbi.nlm.nih.gov/pubmed/26230859 http://dx.doi.org/10.12659/MSM.894786 |
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