Cargando…

Small molecule PZL318: forming fluorescent nanoparticles capable of tracing their interactions with cancer cells and activated platelets, slowing tumor growth and inhibiting thrombosis

Low selectivity of chemotherapy correlates with poor outcomes of cancer patients. To improve this issue, a novel agent, N-(1-[3-methoxycarbonyl-4-hydroxyphenyl]-β-carboline-3-carbonyl)-Trp-Lys-OBzl (PZL318), was reported here. The transmission electron microscopy, scanning electron microscopy, and a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Shan, Wang, Yuji, Wang, Feng, Wang, Yaonan, Zhang, Xiaoyi, Zhao, Ming, Feng, Qiqi, Wu, Jianhui, Zhao, Shurui, Wu, Wei, Peng, Shiqi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554418/ https://www.ncbi.nlm.nih.gov/pubmed/26345234 http://dx.doi.org/10.2147/IJN.S88052

Ejemplares similares

N-(3-hydroxymethyl-β-carboline-1-yl-ethyl- 2-yl)-l-Phe: development toward a nanoscaled antitumor drug capable of treating complicated thrombosis and inflammation
por: Wu, Jianhui, et al.
Publicado: (2017)

ATIQCTPC: a nanomedicine capable of targeting tumor and blocking thrombosis in vivo
por: Xu, Xinyi, et al.
Publicado: (2017)

Dimethyl 2,2′-[2,2′-(ethane-1,1-diyl)bis(1H-indole-3,2-diyl)]-diacetate: a small molecule capable of nano-scale assembly, inhibiting venous thrombosis and inducing no bleeding side effect
por: Wang, Yaonan, et al.
Publicado: (2018)

Development of 13-Cys-BBR as an Agent Having Dual Action of Anti-Thrombosis and Anti-Inflammation
por: Li, Guanyu, et al.
Publicado: (2020)

RGDV-modified gemcitabine: a nano-medicine capable of prolonging half-life, overcoming resistance and eliminating bone marrow toxicity of gemcitabine
por: Liu, Wenchao, et al.
Publicado: (2019)

IQCA-TAVV: To explore the effect of P-selectin, GPIIb/IIIa, IL-2, IL-6 and IL-8 on deep venous thrombosis
por: Wu, Jianhui, et al.
Publicado: (2017)

Nano-scaled MTCA-KKV: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo
por: Zhao, Shurui, et al.
Publicado: (2019)

Cu(2+)-RGDFRGDS: exploring the mechanism and high efficacy of the nanoparticle in antithrombotic therapy
por: Wu, Jianhui, et al.
Publicado: (2015)

Exploring the action of RGDV-gemcitabine on tumor metastasis, tumor growth and possible action pathway
por: Zhang, Xiaoyi, et al.
Publicado: (2020)

13-[CH(2)CO-Cys-(Bzl)-OBzl]-Berberine: Exploring The Correlation Of Anti-Tumor Efficacy With ROS And Apoptosis Protein
por: Li, Guanyu, et al.
Publicado: (2019)

BCESA: a nano-scaled intercalator capable of targeting tumor tissue and releasing anti-tumoral β-carboline-3-carboxylic acid
por: Wu, Jianhui, et al.
Publicado: (2019)

Discovery of DEBIC to correlate P-selectin inhibition and DNA intercalation in cancer therapy and complicated thrombosis
por: Chen, Haiyan, et al.
Publicado: (2017)

Design and synthesis of nanoscaled IQCA-TAVV as a delivery system capable of antiplatelet activation, targeting arterial thrombus and releasing IQCA
por: Wu, Jianhui, et al.
Publicado: (2018)

Docking of THPDTPI: to explore P-selectin as a common target of anti-tumor, anti-thrombotic and anti-inflammatory agent
por: Zhu, Haimei, et al.
Publicado: (2017)

ATIQCTPC targeting MMP-9: a key step to slowing primary tumor growth and inhibiting metastasis of lewis lung carcinoma in vivo
por: Wang, Yuji, et al.
Publicado: (2017)

Modifying tetramethyl–nitrophenyl–imidazoline with amino acids: design, synthesis, and 3D-QSAR for improving inflammatory pain therapy
por: Jiang, Xueyun, et al.
Publicado: (2015)

Design and development of ICCA as a dual inhibitor of GPIIb/IIIa and P-selectin receptors
por: Chen, Haiyan, et al.
Publicado: (2018)

Lytic Bacteriophage PZL-Ah152 as Biocontrol Measures Against Lethal Aeromonas hydrophila Without Distorting Gut Microbiota
por: Feng, Chao, et al.
Publicado: (2022)

Aqueous extract of Rabdosia rubescens leaves: forming nanoparticles, targeting P-selectin, and inhibiting thrombosis
por: Wang, Yuji, et al.
Publicado: (2015)

Modifying ICCA with Trp-Phe-Phe to Enhance in vivo Activity and Form Nano-Medicine
por: Zhang, Xiaoyi, et al.
Publicado: (2020)

Nanoparticles of a New Small-Molecule P-Selectin Inhibitor Attenuate Thrombosis, Inflammation, and Tumor Growth in Two Animal Models
por: Feng, Qiqi, et al.
Publicado: (2021)

RGD(F/S/V)-Dex: towards the development of novel, effective, and safe glucocorticoids
por: Jiang, Xueyun, et al.
Publicado: (2016)

Discovery of novel benzylquinazoline molecules as p97/VCP inhibitors
por: Zhang, Xiaoyi, et al.
Publicado: (2023)

Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect
por: Cui, Chunying, et al.
Publicado: (2013)

Exploring the Relationship between the Inhibition Selectivity and the Apoptosis of Roscovitine-Treated Cancer Cells
por: Cui, Chunying, et al.
Publicado: (2013)

Health Tract No. 318: Recognition Hereafter
Publicado: (1868)

Draft Genome Sequence of Lactobacillus paraplantarum OSY-TC318, a Producer of the Novel Lantibiotic Paraplantaracin TC318
por: Hussein, Walaa E., et al.
Publicado: (2019)

P318: Safety of blood products in Rwanda
por: Florent, S, et al.
Publicado: (2013)

SAT-318 A Case of Metastatic Paraganglioma
por: Mohammadi, Manijeh, et al.
Publicado: (2019)

Reglamento para las construcciones de concreto estructural ACI 318-02 y comentarios ACI 318R-02.
Publicado: (2004)

Reglamento de las construcciones de concreto reforzado (ACI 318-89) y comentarios (ACI 318R-89)
Publicado: (1991)

Requisitos de reglamento para concreto estructural (ACI 318S-05) y comentario (ACI 318SR-05) : (versión en español y en sistema métrico)
Publicado: (2005)

318 Immunological Characteristics of Patients with Bronchial Asthma and Obesity
por: Konischeva, Anna, et al.
Publicado: (2012)

An enhanced photosynthesis and carbohydrate metabolic capability contributes to heterosis of the cotton (Gossypium hirsutum) hybrid ‘Huaza Mian H318’, as revealed by genome-wide gene expression analysis
por: Ding, Yuanhao, et al.
Publicado: (2021)

Requisitos de Reglamento para concreto estructural (ACI 318S-14) y comentario (ACI 318SR-14) : (versión en español y en sistema métrico SI)
Publicado: (2014)

Explorative Study on Isolation and Characterization of a Microviridae G4 Bacteriophage, EMCL318, against Multi-Drug-resistant Escherichia coli 15-318
por: Ghosh, Soumya, et al.
Publicado: (2018)

Characterization of the Xiamenmycin Biosynthesis Gene Cluster in Streptomyces xiamenensis 318
por: Yang, Yong, et al.
Publicado: (2014)

Continuous spinal anaesthesia: A retrospective analysis of 318 cases
por: Beh, Zhi Yuen, et al.
Publicado: (2018)

Characterization of a Novel Thermobifida fusca Bacteriophage P318
por: Cheepudom, Jatuporn, et al.
Publicado: (2019)

5-(Bis(3-(2-hydroxyethyl)-1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHIMHA): showing a strategy of designing drug to block lung metastasis of tumors
por: Gan, Taiping, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_l19sujov9apptpsvghmo7klhjj