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Mitral peak early diastolic filling velocity to deceleration time ratio as a predictor of prognosis in patients with chronic heart failure and preserved or reduced ejection fraction

OBJECTIVE: Doppler derived mitral peak early diastolic filling velocity to deceleration time ratio (E/DT) has been proposed as parameter for predicting prognosis in general population. This study prospectively investigates the incremental prognostic value of E/DT over clinical, conventional echocard...

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Autores principales: Pirozzi, Flora, Paglia, Antonella, Sasso, Laura, Abete, Pasquale, Carlomagno, Angelo, Tocchetti, Carlo G, Bonaduce, Domenico, Petretta, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554776/
https://www.ncbi.nlm.nih.gov/pubmed/26346482
http://dx.doi.org/10.11909/j.issn.1671-5411.2015.04.006
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author Pirozzi, Flora
Paglia, Antonella
Sasso, Laura
Abete, Pasquale
Carlomagno, Angelo
Tocchetti, Carlo G
Bonaduce, Domenico
Petretta, Mario
author_facet Pirozzi, Flora
Paglia, Antonella
Sasso, Laura
Abete, Pasquale
Carlomagno, Angelo
Tocchetti, Carlo G
Bonaduce, Domenico
Petretta, Mario
author_sort Pirozzi, Flora
collection PubMed
description OBJECTIVE: Doppler derived mitral peak early diastolic filling velocity to deceleration time ratio (E/DT) has been proposed as parameter for predicting prognosis in general population. This study prospectively investigates the incremental prognostic value of E/DT over clinical, conventional echocardiographic and mitral-Doppler variables in patients hospitalized for decompensated heart failure (HF). METHODS: We analyzed 95 HF patients (mean age 64.8 ± 12.2 years) hospitalized at our institution from January 2010 to March 2012. The primary end-point was cardiac death or hospitalization, whichever occurred first. Cox regression analysis was performed to identify significant predictors of outcomes. RESULTS: During follow-up (median 37.7 months) 13 patients died and 44 were hospitalized for a cardiac event. At univariable analysis, New York Heart Association (NYHA) functional class, furosemide dosage, lateral tricuspidal annular plane systolic excursion, deceleration time and E/DT were predictive of outcome. At multivariable analysis, E/DT was the only predictor of prognosis (hazard ratio = 1.02, P = 0.018), giving incremental prognostic information to clinical and other echocardio-graphic measures (global chi-square from 15.4 to 25.2; P = 0.032). CONCLUSIONS: E/DT gives independent and incremental prognostic information in HF patients.
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spelling pubmed-45547762015-09-04 Mitral peak early diastolic filling velocity to deceleration time ratio as a predictor of prognosis in patients with chronic heart failure and preserved or reduced ejection fraction Pirozzi, Flora Paglia, Antonella Sasso, Laura Abete, Pasquale Carlomagno, Angelo Tocchetti, Carlo G Bonaduce, Domenico Petretta, Mario J Geriatr Cardiol Research Article OBJECTIVE: Doppler derived mitral peak early diastolic filling velocity to deceleration time ratio (E/DT) has been proposed as parameter for predicting prognosis in general population. This study prospectively investigates the incremental prognostic value of E/DT over clinical, conventional echocardiographic and mitral-Doppler variables in patients hospitalized for decompensated heart failure (HF). METHODS: We analyzed 95 HF patients (mean age 64.8 ± 12.2 years) hospitalized at our institution from January 2010 to March 2012. The primary end-point was cardiac death or hospitalization, whichever occurred first. Cox regression analysis was performed to identify significant predictors of outcomes. RESULTS: During follow-up (median 37.7 months) 13 patients died and 44 were hospitalized for a cardiac event. At univariable analysis, New York Heart Association (NYHA) functional class, furosemide dosage, lateral tricuspidal annular plane systolic excursion, deceleration time and E/DT were predictive of outcome. At multivariable analysis, E/DT was the only predictor of prognosis (hazard ratio = 1.02, P = 0.018), giving incremental prognostic information to clinical and other echocardio-graphic measures (global chi-square from 15.4 to 25.2; P = 0.032). CONCLUSIONS: E/DT gives independent and incremental prognostic information in HF patients. Science Press 2015-07 /pmc/articles/PMC4554776/ /pubmed/26346482 http://dx.doi.org/10.11909/j.issn.1671-5411.2015.04.006 Text en Institute of Geriatric Cardiology http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Research Article
Pirozzi, Flora
Paglia, Antonella
Sasso, Laura
Abete, Pasquale
Carlomagno, Angelo
Tocchetti, Carlo G
Bonaduce, Domenico
Petretta, Mario
Mitral peak early diastolic filling velocity to deceleration time ratio as a predictor of prognosis in patients with chronic heart failure and preserved or reduced ejection fraction
title Mitral peak early diastolic filling velocity to deceleration time ratio as a predictor of prognosis in patients with chronic heart failure and preserved or reduced ejection fraction
title_full Mitral peak early diastolic filling velocity to deceleration time ratio as a predictor of prognosis in patients with chronic heart failure and preserved or reduced ejection fraction
title_fullStr Mitral peak early diastolic filling velocity to deceleration time ratio as a predictor of prognosis in patients with chronic heart failure and preserved or reduced ejection fraction
title_full_unstemmed Mitral peak early diastolic filling velocity to deceleration time ratio as a predictor of prognosis in patients with chronic heart failure and preserved or reduced ejection fraction
title_short Mitral peak early diastolic filling velocity to deceleration time ratio as a predictor of prognosis in patients with chronic heart failure and preserved or reduced ejection fraction
title_sort mitral peak early diastolic filling velocity to deceleration time ratio as a predictor of prognosis in patients with chronic heart failure and preserved or reduced ejection fraction
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554776/
https://www.ncbi.nlm.nih.gov/pubmed/26346482
http://dx.doi.org/10.11909/j.issn.1671-5411.2015.04.006
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