Cargando…
The Cardiomyopathy Lamin A/C D192G Mutation Disrupts Whole-Cell Biomechanics in Cardiomyocytes as Measured by Atomic Force Microscopy Loading-Unloading Curve Analysis
Atomic force microscopy (AFM) cell loading/unloading curves were used to provide comprehensive insights into biomechanical behavior of cardiomyocytes carrying the lamin A/C (LMNA) D192G mutation known to cause defective nuclear wall, myopathy and severe cardiomyopathy. Our results suggested that the...
Autores principales: | Lanzicher, Thomas, Martinelli, Valentina, Puzzi, Luca, Del Favero, Giorgia, Codan, Barbara, Long, Carlin S., Mestroni, Luisa, Taylor, Matthew R. G., Sbaizero, Orfeo |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555041/ https://www.ncbi.nlm.nih.gov/pubmed/26323789 http://dx.doi.org/10.1038/srep13388 |
Ejemplares similares
-
Compromised Biomechanical Properties, Cell–Cell Adhesion and Nanotubes Communication in Cardiac Fibroblasts Carrying the Lamin A/C D192G Mutation
por: Lachaize, Veronique, et al.
Publicado: (2021) -
Cellular Biomechanic
Impairment in Cardiomyocytes
Carrying the Progeria Mutation: An Atomic Force Microscopy Investigation
por: Peña, Brisa, et al.
Publicado: (2022) -
Altered microtubule structure, hemichannel localization and beating activity in cardiomyocytes expressing pathologic nuclear lamin A/C
por: Borin, Daniele, et al.
Publicado: (2020) -
Current Understanding of the Role of Cytoskeletal Cross-Linkers in the Onset and Development of Cardiomyopathies
por: Pecorari, Ilaria, et al.
Publicado: (2020) -
Atomic Force Microscopy (AFM) Applications in Arrhythmogenic Cardiomyopathy
por: Peña, Brisa, et al.
Publicado: (2022)