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Higher Body Iron Is Associated with Greater Depression Symptoms among Young Adult Men but not Women: Observational Data from the Daily Life Study

Studies investigating possible associations between iron status and mood or depressive symptoms have reported inconsistent results. However, they have neither used body iron to measure iron status nor measured mood using daily measures. We investigated whether body iron was associated with depressiv...

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Autores principales: Richardson, Aimee C., Heath, Anne-Louise M., Haszard, Jillian J., Polak, Maria A., Houghton, Lisa A., Conner, Tamlin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555109/
https://www.ncbi.nlm.nih.gov/pubmed/26213963
http://dx.doi.org/10.3390/nu7085270
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author Richardson, Aimee C.
Heath, Anne-Louise M.
Haszard, Jillian J.
Polak, Maria A.
Houghton, Lisa A.
Conner, Tamlin S.
author_facet Richardson, Aimee C.
Heath, Anne-Louise M.
Haszard, Jillian J.
Polak, Maria A.
Houghton, Lisa A.
Conner, Tamlin S.
author_sort Richardson, Aimee C.
collection PubMed
description Studies investigating possible associations between iron status and mood or depressive symptoms have reported inconsistent results. However, they have neither used body iron to measure iron status nor measured mood using daily measures. We investigated whether body iron was associated with depressive symptoms, daily mood, daily tiredness, difficulty concentrating, and stress in young adult women and men. Young adult (17–25 years) women (n = 562) and men (n = 323) completed the Center for Epidemiologic Studies Depression Scale, then reported negative and positive mood, and other states daily for 13 days. Non-fasting venous blood was collected to determine hemoglobin, serum ferritin and soluble transferrin receptor (to calculate body iron), C-reactive protein, and alpha-1-acid glycoprotein concentration. Regression models tested linear associations between body iron and the outcome variables, controlling for possible confounders. No associations were found between body iron and the outcome variables in women. However, higher body iron was associated with more depressive symptoms in men (3.4% more per body iron mg/kg; 95% confidence intervals (CI): 0.8%, 5.9%). In young adult women, body iron is unlikely to be associated with significant deficits in mood or depressive symptoms. However, higher body iron may be associated with more depressive symptoms in young adult men.
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spelling pubmed-45551092015-09-01 Higher Body Iron Is Associated with Greater Depression Symptoms among Young Adult Men but not Women: Observational Data from the Daily Life Study Richardson, Aimee C. Heath, Anne-Louise M. Haszard, Jillian J. Polak, Maria A. Houghton, Lisa A. Conner, Tamlin S. Nutrients Article Studies investigating possible associations between iron status and mood or depressive symptoms have reported inconsistent results. However, they have neither used body iron to measure iron status nor measured mood using daily measures. We investigated whether body iron was associated with depressive symptoms, daily mood, daily tiredness, difficulty concentrating, and stress in young adult women and men. Young adult (17–25 years) women (n = 562) and men (n = 323) completed the Center for Epidemiologic Studies Depression Scale, then reported negative and positive mood, and other states daily for 13 days. Non-fasting venous blood was collected to determine hemoglobin, serum ferritin and soluble transferrin receptor (to calculate body iron), C-reactive protein, and alpha-1-acid glycoprotein concentration. Regression models tested linear associations between body iron and the outcome variables, controlling for possible confounders. No associations were found between body iron and the outcome variables in women. However, higher body iron was associated with more depressive symptoms in men (3.4% more per body iron mg/kg; 95% confidence intervals (CI): 0.8%, 5.9%). In young adult women, body iron is unlikely to be associated with significant deficits in mood or depressive symptoms. However, higher body iron may be associated with more depressive symptoms in young adult men. MDPI 2015-07-23 /pmc/articles/PMC4555109/ /pubmed/26213963 http://dx.doi.org/10.3390/nu7085270 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Richardson, Aimee C.
Heath, Anne-Louise M.
Haszard, Jillian J.
Polak, Maria A.
Houghton, Lisa A.
Conner, Tamlin S.
Higher Body Iron Is Associated with Greater Depression Symptoms among Young Adult Men but not Women: Observational Data from the Daily Life Study
title Higher Body Iron Is Associated with Greater Depression Symptoms among Young Adult Men but not Women: Observational Data from the Daily Life Study
title_full Higher Body Iron Is Associated with Greater Depression Symptoms among Young Adult Men but not Women: Observational Data from the Daily Life Study
title_fullStr Higher Body Iron Is Associated with Greater Depression Symptoms among Young Adult Men but not Women: Observational Data from the Daily Life Study
title_full_unstemmed Higher Body Iron Is Associated with Greater Depression Symptoms among Young Adult Men but not Women: Observational Data from the Daily Life Study
title_short Higher Body Iron Is Associated with Greater Depression Symptoms among Young Adult Men but not Women: Observational Data from the Daily Life Study
title_sort higher body iron is associated with greater depression symptoms among young adult men but not women: observational data from the daily life study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555109/
https://www.ncbi.nlm.nih.gov/pubmed/26213963
http://dx.doi.org/10.3390/nu7085270
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