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Immune Modulation by Vitamin D and Its Relevance to Food Allergy

Apart from its classical function in bone and calcium metabolism, vitamin D is also involved in immune regulation and has been linked to various cancers, immune disorders and allergic diseases. Within the innate and adaptive immune systems, the vitamin D receptor and enzymes in monocytes, dendritic...

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Autores principales: Suaini, Noor H. A., Zhang, Yuxia, Vuillermin, Peter J., Allen, Katrina J., Harrison, Leonard C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555110/
https://www.ncbi.nlm.nih.gov/pubmed/26225992
http://dx.doi.org/10.3390/nu7085271
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author Suaini, Noor H. A.
Zhang, Yuxia
Vuillermin, Peter J.
Allen, Katrina J.
Harrison, Leonard C.
author_facet Suaini, Noor H. A.
Zhang, Yuxia
Vuillermin, Peter J.
Allen, Katrina J.
Harrison, Leonard C.
author_sort Suaini, Noor H. A.
collection PubMed
description Apart from its classical function in bone and calcium metabolism, vitamin D is also involved in immune regulation and has been linked to various cancers, immune disorders and allergic diseases. Within the innate and adaptive immune systems, the vitamin D receptor and enzymes in monocytes, dendritic cells, epithelial cells, T lymphocytes and B lymphocytes mediate the immune modulatory actions of vitamin D. Vitamin D insufficiency/deficiency early in life has been identified as one of the risk factors for food allergy. Several studies have observed an association between increasing latitude and food allergy prevalence, plausibly linked to lower ultraviolet radiation (UVR) exposure and vitamin D synthesis in the skin. Along with mounting epidemiological evidence of a link between vitamin D status and food allergy, mice and human studies have shed light on the modulatory properties of vitamin D on the innate and adaptive immune systems. This review will summarize the literature on the metabolism and immune modulatory properties of vitamin D, with particular reference to food allergy.
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spelling pubmed-45551102015-09-01 Immune Modulation by Vitamin D and Its Relevance to Food Allergy Suaini, Noor H. A. Zhang, Yuxia Vuillermin, Peter J. Allen, Katrina J. Harrison, Leonard C. Nutrients Review Apart from its classical function in bone and calcium metabolism, vitamin D is also involved in immune regulation and has been linked to various cancers, immune disorders and allergic diseases. Within the innate and adaptive immune systems, the vitamin D receptor and enzymes in monocytes, dendritic cells, epithelial cells, T lymphocytes and B lymphocytes mediate the immune modulatory actions of vitamin D. Vitamin D insufficiency/deficiency early in life has been identified as one of the risk factors for food allergy. Several studies have observed an association between increasing latitude and food allergy prevalence, plausibly linked to lower ultraviolet radiation (UVR) exposure and vitamin D synthesis in the skin. Along with mounting epidemiological evidence of a link between vitamin D status and food allergy, mice and human studies have shed light on the modulatory properties of vitamin D on the innate and adaptive immune systems. This review will summarize the literature on the metabolism and immune modulatory properties of vitamin D, with particular reference to food allergy. MDPI 2015-07-27 /pmc/articles/PMC4555110/ /pubmed/26225992 http://dx.doi.org/10.3390/nu7085271 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Suaini, Noor H. A.
Zhang, Yuxia
Vuillermin, Peter J.
Allen, Katrina J.
Harrison, Leonard C.
Immune Modulation by Vitamin D and Its Relevance to Food Allergy
title Immune Modulation by Vitamin D and Its Relevance to Food Allergy
title_full Immune Modulation by Vitamin D and Its Relevance to Food Allergy
title_fullStr Immune Modulation by Vitamin D and Its Relevance to Food Allergy
title_full_unstemmed Immune Modulation by Vitamin D and Its Relevance to Food Allergy
title_short Immune Modulation by Vitamin D and Its Relevance to Food Allergy
title_sort immune modulation by vitamin d and its relevance to food allergy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555110/
https://www.ncbi.nlm.nih.gov/pubmed/26225992
http://dx.doi.org/10.3390/nu7085271
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