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Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model

Methylmercury is well known for causing adverse health effects in the brain and nervous system. Estimating the elimination constant derived from the biological half-life of methylmercury in the blood or hair is an important part of calculating guidelines for methylmercury intake. Thus, this study wa...

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Detalles Bibliográficos
Autores principales: Jo, Seongil, Woo, Hae Dong, Kwon, Ho-Jang, Oh, Se-Young, Park, Jung-Duck, Hong, Young-Seoub, Pyo, Heesoo, Park, Kyung Su, Ha, Mina, Kim, Ho, Sohn, Seok-Joon, Kim, Yu-Mi, Lim, Ji-Ae, Lee, Sang-Ah, Eom, Sang-Yong, Kim, Byoung-Gwon, Lee, Kyoung-Mu, Lee, Jong-Hyeon, Hwang, Myung Sil, Kim, Jeongseon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555264/
https://www.ncbi.nlm.nih.gov/pubmed/26264017
http://dx.doi.org/10.3390/ijerph120809054
Descripción
Sumario:Methylmercury is well known for causing adverse health effects in the brain and nervous system. Estimating the elimination constant derived from the biological half-life of methylmercury in the blood or hair is an important part of calculating guidelines for methylmercury intake. Thus, this study was conducted to estimate the biological half-life of methylmercury in Korean adults. We used a one-compartment model with a direct relationship between methylmercury concentrations in the blood and daily dietary intake of methylmercury. We quantified the between-person variability of the methylmercury half-life in the population, and informative priors were used to estimate the parameters in the model. The population half-life of methylmercury was estimated to be 80.2 ± 8.6 days. The population mean of the methylmercury half-life was 81.6 ± 8.4 days for men and 78.9 ± 8.6 days for women. The standard deviation of the half-life was estimated at 25.0 ± 8.6 days. Using the direct relationship between methylmercury concentrations in blood and methylmercury intake, the biological half-life in this study was estimated to be longer than indicated by the earlier studies that have been used to set guideline values.