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Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model
Methylmercury is well known for causing adverse health effects in the brain and nervous system. Estimating the elimination constant derived from the biological half-life of methylmercury in the blood or hair is an important part of calculating guidelines for methylmercury intake. Thus, this study wa...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555264/ https://www.ncbi.nlm.nih.gov/pubmed/26264017 http://dx.doi.org/10.3390/ijerph120809054 |
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author | Jo, Seongil Woo, Hae Dong Kwon, Ho-Jang Oh, Se-Young Park, Jung-Duck Hong, Young-Seoub Pyo, Heesoo Park, Kyung Su Ha, Mina Kim, Ho Sohn, Seok-Joon Kim, Yu-Mi Lim, Ji-Ae Lee, Sang-Ah Eom, Sang-Yong Kim, Byoung-Gwon Lee, Kyoung-Mu Lee, Jong-Hyeon Hwang, Myung Sil Kim, Jeongseon |
author_facet | Jo, Seongil Woo, Hae Dong Kwon, Ho-Jang Oh, Se-Young Park, Jung-Duck Hong, Young-Seoub Pyo, Heesoo Park, Kyung Su Ha, Mina Kim, Ho Sohn, Seok-Joon Kim, Yu-Mi Lim, Ji-Ae Lee, Sang-Ah Eom, Sang-Yong Kim, Byoung-Gwon Lee, Kyoung-Mu Lee, Jong-Hyeon Hwang, Myung Sil Kim, Jeongseon |
author_sort | Jo, Seongil |
collection | PubMed |
description | Methylmercury is well known for causing adverse health effects in the brain and nervous system. Estimating the elimination constant derived from the biological half-life of methylmercury in the blood or hair is an important part of calculating guidelines for methylmercury intake. Thus, this study was conducted to estimate the biological half-life of methylmercury in Korean adults. We used a one-compartment model with a direct relationship between methylmercury concentrations in the blood and daily dietary intake of methylmercury. We quantified the between-person variability of the methylmercury half-life in the population, and informative priors were used to estimate the parameters in the model. The population half-life of methylmercury was estimated to be 80.2 ± 8.6 days. The population mean of the methylmercury half-life was 81.6 ± 8.4 days for men and 78.9 ± 8.6 days for women. The standard deviation of the half-life was estimated at 25.0 ± 8.6 days. Using the direct relationship between methylmercury concentrations in blood and methylmercury intake, the biological half-life in this study was estimated to be longer than indicated by the earlier studies that have been used to set guideline values. |
format | Online Article Text |
id | pubmed-4555264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-45552642015-09-01 Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model Jo, Seongil Woo, Hae Dong Kwon, Ho-Jang Oh, Se-Young Park, Jung-Duck Hong, Young-Seoub Pyo, Heesoo Park, Kyung Su Ha, Mina Kim, Ho Sohn, Seok-Joon Kim, Yu-Mi Lim, Ji-Ae Lee, Sang-Ah Eom, Sang-Yong Kim, Byoung-Gwon Lee, Kyoung-Mu Lee, Jong-Hyeon Hwang, Myung Sil Kim, Jeongseon Int J Environ Res Public Health Article Methylmercury is well known for causing adverse health effects in the brain and nervous system. Estimating the elimination constant derived from the biological half-life of methylmercury in the blood or hair is an important part of calculating guidelines for methylmercury intake. Thus, this study was conducted to estimate the biological half-life of methylmercury in Korean adults. We used a one-compartment model with a direct relationship between methylmercury concentrations in the blood and daily dietary intake of methylmercury. We quantified the between-person variability of the methylmercury half-life in the population, and informative priors were used to estimate the parameters in the model. The population half-life of methylmercury was estimated to be 80.2 ± 8.6 days. The population mean of the methylmercury half-life was 81.6 ± 8.4 days for men and 78.9 ± 8.6 days for women. The standard deviation of the half-life was estimated at 25.0 ± 8.6 days. Using the direct relationship between methylmercury concentrations in blood and methylmercury intake, the biological half-life in this study was estimated to be longer than indicated by the earlier studies that have been used to set guideline values. MDPI 2015-07-31 2015-08 /pmc/articles/PMC4555264/ /pubmed/26264017 http://dx.doi.org/10.3390/ijerph120809054 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jo, Seongil Woo, Hae Dong Kwon, Ho-Jang Oh, Se-Young Park, Jung-Duck Hong, Young-Seoub Pyo, Heesoo Park, Kyung Su Ha, Mina Kim, Ho Sohn, Seok-Joon Kim, Yu-Mi Lim, Ji-Ae Lee, Sang-Ah Eom, Sang-Yong Kim, Byoung-Gwon Lee, Kyoung-Mu Lee, Jong-Hyeon Hwang, Myung Sil Kim, Jeongseon Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model |
title | Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model |
title_full | Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model |
title_fullStr | Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model |
title_full_unstemmed | Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model |
title_short | Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model |
title_sort | estimation of the biological half-life of methylmercury using a population toxicokinetic model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555264/ https://www.ncbi.nlm.nih.gov/pubmed/26264017 http://dx.doi.org/10.3390/ijerph120809054 |
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