Cargando…
Pregnancy in Women with Systemic Lupus Erythematosus: A Retrospective Study of 83 Pregnancies at a Single Centre
Objective: To evaluate the outcome of 80 pregnant women with systemic lupus erythematosus (SLE) and explore the risk factors for lupus flare, obstetric complications and fetal loss. Methods: 83 pregnancies in 80 women were divided into three groups. Group A: patients in remission for > 6 months b...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555317/ https://www.ncbi.nlm.nih.gov/pubmed/26295404 http://dx.doi.org/10.3390/ijerph120809876 |
_version_ | 1782388178697584640 |
---|---|
author | Chen, Shanying Sun, Xuejuan Wu, Bide Lian, Xuejian |
author_facet | Chen, Shanying Sun, Xuejuan Wu, Bide Lian, Xuejian |
author_sort | Chen, Shanying |
collection | PubMed |
description | Objective: To evaluate the outcome of 80 pregnant women with systemic lupus erythematosus (SLE) and explore the risk factors for lupus flare, obstetric complications and fetal loss. Methods: 83 pregnancies in 80 women were divided into three groups. Group A: patients in remission for > 6 months before pregnancy, proteinuria < 0.5 g per day, without renal failure and discontinuation of cytotoxic drugs for > one year; Group B: patients with SLE disease activity in the six months before pregnancy; Group C: patients with new onset SLE during pregnancy. Results: In group A, 76.47% pregnancies achieved full-term deliveries and 80.39% achieved live born infants. In group B and C, the outcome was poor. Among 62 patients (64 pregnancies) diagnosed as SLE before pregnancy, SLE flares occurred in 27 (42.19%) pregnancies. SLE disease activity in the six months before pregnancy was significantly associated with lupus flare (OR 5.00, 95% CI 1.14–21.87, p = 0.03) and fetal loss. New onset lupus during pregnancy was independently associated with obstetric complications (OR 7.22, 95% CI 2.14–24.38, p = 0.001). Conclusions: The current study confirmed the previous report that SLE should be considered a high risk of pregnancy. If pregnancy is planned after remission for > 6 months, the favorable outcome can be achieved. |
format | Online Article Text |
id | pubmed-4555317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-45553172015-09-01 Pregnancy in Women with Systemic Lupus Erythematosus: A Retrospective Study of 83 Pregnancies at a Single Centre Chen, Shanying Sun, Xuejuan Wu, Bide Lian, Xuejian Int J Environ Res Public Health Article Objective: To evaluate the outcome of 80 pregnant women with systemic lupus erythematosus (SLE) and explore the risk factors for lupus flare, obstetric complications and fetal loss. Methods: 83 pregnancies in 80 women were divided into three groups. Group A: patients in remission for > 6 months before pregnancy, proteinuria < 0.5 g per day, without renal failure and discontinuation of cytotoxic drugs for > one year; Group B: patients with SLE disease activity in the six months before pregnancy; Group C: patients with new onset SLE during pregnancy. Results: In group A, 76.47% pregnancies achieved full-term deliveries and 80.39% achieved live born infants. In group B and C, the outcome was poor. Among 62 patients (64 pregnancies) diagnosed as SLE before pregnancy, SLE flares occurred in 27 (42.19%) pregnancies. SLE disease activity in the six months before pregnancy was significantly associated with lupus flare (OR 5.00, 95% CI 1.14–21.87, p = 0.03) and fetal loss. New onset lupus during pregnancy was independently associated with obstetric complications (OR 7.22, 95% CI 2.14–24.38, p = 0.001). Conclusions: The current study confirmed the previous report that SLE should be considered a high risk of pregnancy. If pregnancy is planned after remission for > 6 months, the favorable outcome can be achieved. MDPI 2015-08-19 2015-08 /pmc/articles/PMC4555317/ /pubmed/26295404 http://dx.doi.org/10.3390/ijerph120809876 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chen, Shanying Sun, Xuejuan Wu, Bide Lian, Xuejian Pregnancy in Women with Systemic Lupus Erythematosus: A Retrospective Study of 83 Pregnancies at a Single Centre |
title | Pregnancy in Women with Systemic Lupus Erythematosus: A Retrospective Study of 83 Pregnancies at a Single Centre |
title_full | Pregnancy in Women with Systemic Lupus Erythematosus: A Retrospective Study of 83 Pregnancies at a Single Centre |
title_fullStr | Pregnancy in Women with Systemic Lupus Erythematosus: A Retrospective Study of 83 Pregnancies at a Single Centre |
title_full_unstemmed | Pregnancy in Women with Systemic Lupus Erythematosus: A Retrospective Study of 83 Pregnancies at a Single Centre |
title_short | Pregnancy in Women with Systemic Lupus Erythematosus: A Retrospective Study of 83 Pregnancies at a Single Centre |
title_sort | pregnancy in women with systemic lupus erythematosus: a retrospective study of 83 pregnancies at a single centre |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555317/ https://www.ncbi.nlm.nih.gov/pubmed/26295404 http://dx.doi.org/10.3390/ijerph120809876 |
work_keys_str_mv | AT chenshanying pregnancyinwomenwithsystemiclupuserythematosusaretrospectivestudyof83pregnanciesatasinglecentre AT sunxuejuan pregnancyinwomenwithsystemiclupuserythematosusaretrospectivestudyof83pregnanciesatasinglecentre AT wubide pregnancyinwomenwithsystemiclupuserythematosusaretrospectivestudyof83pregnanciesatasinglecentre AT lianxuejian pregnancyinwomenwithsystemiclupuserythematosusaretrospectivestudyof83pregnanciesatasinglecentre |