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Constitutive and ghrelin-dependent GHSR1a activation impairs Ca(V)2.1 and Ca(V)2.2 currents in hypothalamic neurons

The growth hormone secretagogue receptor type 1a (GHSR1a) has the highest known constitutive activity of any G protein–coupled receptor (GPCR). GHSR1a mediates the action of the hormone ghrelin, and its activation increases transcriptional and electrical activity in hypothalamic neurons. Although GH...

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Detalles Bibliográficos
Autores principales:	López Soto, Eduardo Javier, Agosti, Francina, Cabral, Agustina, Mustafa, Emilio Roman, Damonte, Valentina Martínez, Gandini, Maria Alejandra, Rodríguez, Silvia, Castrogiovanni, Daniel, Felix, Ricardo, Perelló, Mario, Raingo, Jesica
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555474/ https://www.ncbi.nlm.nih.gov/pubmed/26283199 http://dx.doi.org/10.1085/jgp.201511383

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