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Squamous cell carcinoma on a syphilitic gumma: A unique presentation
Gumma is a characteristic lesion of tertiary syphilis that is rare nowadays, but still rarer is squamous cell carcinoma (SCC) arising from it. A 74-year-old male presented with throat pain and nasal twang with a past history of genital ulcer. Examination revealed a well-defined ulcer with a perforat...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555910/ https://www.ncbi.nlm.nih.gov/pubmed/26392665 http://dx.doi.org/10.4103/2589-0557.156745 |
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author | Rahima, S. Riyaz, Najeeba Latheef, E.N. Abdul Shyni, P.M. |
author_facet | Rahima, S. Riyaz, Najeeba Latheef, E.N. Abdul Shyni, P.M. |
author_sort | Rahima, S. |
collection | PubMed |
description | Gumma is a characteristic lesion of tertiary syphilis that is rare nowadays, but still rarer is squamous cell carcinoma (SCC) arising from it. A 74-year-old male presented with throat pain and nasal twang with a past history of genital ulcer. Examination revealed a well-defined ulcer with a perforation of 1.5 cm over the hard palate with induration and nodularity at the margins. This patient also had leukoplakia over the ventral aspect of the tongue. His treponema pallidum hemagglutination assay was positive, and biopsy revealed well-differentiated SCC from the lesion over the palate and leukoplakia with dysplasia from the lesion over the tongue. Patient is on treatment from radiotherapy. To conclude, this is a unique presentation of syphilitic gumma with palatal perforation with SCC and syphilitic leukoplakia with Ca in situ over tongue. Thus, serology for syphilis should be done in all patients with SCC of the oral cavity. |
format | Online Article Text |
id | pubmed-4555910 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-45559102015-09-21 Squamous cell carcinoma on a syphilitic gumma: A unique presentation Rahima, S. Riyaz, Najeeba Latheef, E.N. Abdul Shyni, P.M. Indian J Sex Transm Dis AIDS Case Report Gumma is a characteristic lesion of tertiary syphilis that is rare nowadays, but still rarer is squamous cell carcinoma (SCC) arising from it. A 74-year-old male presented with throat pain and nasal twang with a past history of genital ulcer. Examination revealed a well-defined ulcer with a perforation of 1.5 cm over the hard palate with induration and nodularity at the margins. This patient also had leukoplakia over the ventral aspect of the tongue. His treponema pallidum hemagglutination assay was positive, and biopsy revealed well-differentiated SCC from the lesion over the palate and leukoplakia with dysplasia from the lesion over the tongue. Patient is on treatment from radiotherapy. To conclude, this is a unique presentation of syphilitic gumma with palatal perforation with SCC and syphilitic leukoplakia with Ca in situ over tongue. Thus, serology for syphilis should be done in all patients with SCC of the oral cavity. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4555910/ /pubmed/26392665 http://dx.doi.org/10.4103/2589-0557.156745 Text en Copyright: © Indian Journal of Sexually Transmitted Diseases and AIDS http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Rahima, S. Riyaz, Najeeba Latheef, E.N. Abdul Shyni, P.M. Squamous cell carcinoma on a syphilitic gumma: A unique presentation |
title | Squamous cell carcinoma on a syphilitic gumma: A unique presentation |
title_full | Squamous cell carcinoma on a syphilitic gumma: A unique presentation |
title_fullStr | Squamous cell carcinoma on a syphilitic gumma: A unique presentation |
title_full_unstemmed | Squamous cell carcinoma on a syphilitic gumma: A unique presentation |
title_short | Squamous cell carcinoma on a syphilitic gumma: A unique presentation |
title_sort | squamous cell carcinoma on a syphilitic gumma: a unique presentation |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555910/ https://www.ncbi.nlm.nih.gov/pubmed/26392665 http://dx.doi.org/10.4103/2589-0557.156745 |
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