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Assessment of global DNA methylation in peripheral blood cell subpopulations of early rheumatoid arthritis before and after methotrexate

INTRODUCTION: DNA methylation is an epigenetic mechanism regulating gene expression that has been insufficiently studied in the blood of rheumatoid arthritis (RA) patients, as only T cells and total peripheral blood mononuclear cells (PBMCs) from patients with established RA have been studied and wi...

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Detalles Bibliográficos
Autores principales: de Andres, María C., Perez-Pampin, Eva, Calaza, Manuel, Santaclara, Francisco J., Ortea, Ignacio, Gomez-Reino, Juan J., Gonzalez, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556005/
https://www.ncbi.nlm.nih.gov/pubmed/26330155
http://dx.doi.org/10.1186/s13075-015-0748-5