Precision renal medicine: a roadmap towards targeted kidney fibrosis therapies

Based on extensive pre-clinical achievements over the past decades, it appears to be due time for a successful clinical translation in the renal fibrosis field—but what is the quickest road to get there? In light of the recent launch of the Precision Medicine Initiative and success of molecularly in...

Descripción completa

Detalles Bibliográficos
Autores principales: Zeisberg, Michael, Zeisberg, Elisabeth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556008/
https://www.ncbi.nlm.nih.gov/pubmed/26330891
http://dx.doi.org/10.1186/s13069-015-0033-x
_version_ 1782388286821498880
author Zeisberg, Michael
Zeisberg, Elisabeth M.
author_facet Zeisberg, Michael
Zeisberg, Elisabeth M.
author_sort Zeisberg, Michael
collection PubMed
description Based on extensive pre-clinical achievements over the past decades, it appears to be due time for a successful clinical translation in the renal fibrosis field—but what is the quickest road to get there? In light of the recent launch of the Precision Medicine Initiative and success of molecularly informed drugs in oncology, we here discuss what it may take to bring molecularly targeted anti-fibrotic to clinical use in chronic progressive kidney disease.
format Online
Article
Text
id pubmed-4556008
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-45560082015-09-02 Precision renal medicine: a roadmap towards targeted kidney fibrosis therapies Zeisberg, Michael Zeisberg, Elisabeth M. Fibrogenesis Tissue Repair Review Based on extensive pre-clinical achievements over the past decades, it appears to be due time for a successful clinical translation in the renal fibrosis field—but what is the quickest road to get there? In light of the recent launch of the Precision Medicine Initiative and success of molecularly informed drugs in oncology, we here discuss what it may take to bring molecularly targeted anti-fibrotic to clinical use in chronic progressive kidney disease. BioMed Central 2015-09-01 /pmc/articles/PMC4556008/ /pubmed/26330891 http://dx.doi.org/10.1186/s13069-015-0033-x Text en © Zeisberg and Zeisberg. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Zeisberg, Michael
Zeisberg, Elisabeth M.
Precision renal medicine: a roadmap towards targeted kidney fibrosis therapies
title Precision renal medicine: a roadmap towards targeted kidney fibrosis therapies
title_full Precision renal medicine: a roadmap towards targeted kidney fibrosis therapies
title_fullStr Precision renal medicine: a roadmap towards targeted kidney fibrosis therapies
title_full_unstemmed Precision renal medicine: a roadmap towards targeted kidney fibrosis therapies
title_short Precision renal medicine: a roadmap towards targeted kidney fibrosis therapies
title_sort precision renal medicine: a roadmap towards targeted kidney fibrosis therapies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556008/
https://www.ncbi.nlm.nih.gov/pubmed/26330891
http://dx.doi.org/10.1186/s13069-015-0033-x
work_keys_str_mv AT zeisbergmichael precisionrenalmedicinearoadmaptowardstargetedkidneyfibrosistherapies
AT zeisbergelisabethm precisionrenalmedicinearoadmaptowardstargetedkidneyfibrosistherapies

Ejemplares similares