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Prognostic value of FDG PET/CT in head and neck squamous cell carcinomas

INTRODUCTION: The purpose of this study was to evaluate the use of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) to identify the presence of cervical lymph nodes metastases and extracapsular spread with histologic correlations in head and neck squamous...

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Autores principales: Dequanter, D, Shahla, M, Aubert, C, Deniz, Y, Lothaire, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556030/
https://www.ncbi.nlm.nih.gov/pubmed/26346890
http://dx.doi.org/10.2147/OTT.S85479
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author Dequanter, D
Shahla, M
Aubert, C
Deniz, Y
Lothaire, P
author_facet Dequanter, D
Shahla, M
Aubert, C
Deniz, Y
Lothaire, P
author_sort Dequanter, D
collection PubMed
description INTRODUCTION: The purpose of this study was to evaluate the use of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) to identify the presence of cervical lymph nodes metastases and extracapsular spread with histologic correlations in head and neck squamous cell carcinoma. METHODS: The medical records of 54 patients who underwent (18)F-FDG PET/CT for head and neck squamous cell carcinoma before surgery were reviewed. Receiver operating characteristic (ROC) analysis was performed to differentiate patients with cervical lymph node metastasis from those without lymph node metastasis. The same statistical analysis was done to differentiate cervical lymph nodes with extracapsular spread from those without extracapsular spread. RESULTS: Metastatic disease was diagnosed histologically in 49% (26 of 54) of the patients. Extracapsular spread was present in ten of the 54 patients (19%). When ROC curve analysis and maximum standardized uptake (SUV(max)) values were used to detect cervical lymph node metastasis, the area under the ROC curve was 0.96 and the optimal cutoff value for SUV(max) was 4.05 based on ROC curve analysis. The sensitivity and specificity of SUV(max) for the detection of cervical lymph node metastasis using this cutoff point were 92% and 88%, respectively. When ROC curve analysis and SUV(max) values were used in order to detect extracapsular spread, the area under the ROC curve was 0.86, and the optimal cutoff value for SUV(max) was 4.15 based on ROC curve analysis. Using this cutoff value, the sensitivity and specificity of SUV(max) for the detection of extracapsular spread were 83% and 88%, respectively. CONCLUSION: In our study, a median (18)F-FDG PET/CT SUV(max) cutoff value of 4.15 was found to be related with cervical lymph node metastasis and extracapsular spread in patients with head and neck cancer.
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spelling pubmed-45560302015-09-04 Prognostic value of FDG PET/CT in head and neck squamous cell carcinomas Dequanter, D Shahla, M Aubert, C Deniz, Y Lothaire, P Onco Targets Ther Original Research INTRODUCTION: The purpose of this study was to evaluate the use of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) to identify the presence of cervical lymph nodes metastases and extracapsular spread with histologic correlations in head and neck squamous cell carcinoma. METHODS: The medical records of 54 patients who underwent (18)F-FDG PET/CT for head and neck squamous cell carcinoma before surgery were reviewed. Receiver operating characteristic (ROC) analysis was performed to differentiate patients with cervical lymph node metastasis from those without lymph node metastasis. The same statistical analysis was done to differentiate cervical lymph nodes with extracapsular spread from those without extracapsular spread. RESULTS: Metastatic disease was diagnosed histologically in 49% (26 of 54) of the patients. Extracapsular spread was present in ten of the 54 patients (19%). When ROC curve analysis and maximum standardized uptake (SUV(max)) values were used to detect cervical lymph node metastasis, the area under the ROC curve was 0.96 and the optimal cutoff value for SUV(max) was 4.05 based on ROC curve analysis. The sensitivity and specificity of SUV(max) for the detection of cervical lymph node metastasis using this cutoff point were 92% and 88%, respectively. When ROC curve analysis and SUV(max) values were used in order to detect extracapsular spread, the area under the ROC curve was 0.86, and the optimal cutoff value for SUV(max) was 4.15 based on ROC curve analysis. Using this cutoff value, the sensitivity and specificity of SUV(max) for the detection of extracapsular spread were 83% and 88%, respectively. CONCLUSION: In our study, a median (18)F-FDG PET/CT SUV(max) cutoff value of 4.15 was found to be related with cervical lymph node metastasis and extracapsular spread in patients with head and neck cancer. Dove Medical Press 2015-08-26 /pmc/articles/PMC4556030/ /pubmed/26346890 http://dx.doi.org/10.2147/OTT.S85479 Text en © 2015 Dequanter et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Dequanter, D
Shahla, M
Aubert, C
Deniz, Y
Lothaire, P
Prognostic value of FDG PET/CT in head and neck squamous cell carcinomas
title Prognostic value of FDG PET/CT in head and neck squamous cell carcinomas
title_full Prognostic value of FDG PET/CT in head and neck squamous cell carcinomas
title_fullStr Prognostic value of FDG PET/CT in head and neck squamous cell carcinomas
title_full_unstemmed Prognostic value of FDG PET/CT in head and neck squamous cell carcinomas
title_short Prognostic value of FDG PET/CT in head and neck squamous cell carcinomas
title_sort prognostic value of fdg pet/ct in head and neck squamous cell carcinomas
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556030/
https://www.ncbi.nlm.nih.gov/pubmed/26346890
http://dx.doi.org/10.2147/OTT.S85479
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