Cargando…

Evaluation of Apelin and Insulin Resistance in Patients with PCOS and Therapeutic Effect of Drospirenone-Ethinylestradiol Plus Metformin

BACKGROUND: The aim of this study was to determine the relevance of apelin and insulin resistance (IR) with polycystic ovary syndrome (PCOS) and to assess the possible therapeutic effect of the combined therapy of drospirenone-ethinylestradiol (DRSP-EE) combined with metformin. MATERIAL/METHODS: Six...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Xianchang, Wu, Xingguo, Zhou, Yan, Yu, Xinyan, Zhang, Wenjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556163/
https://www.ncbi.nlm.nih.gov/pubmed/26314870
http://dx.doi.org/10.12659/MSM.894926
_version_ 1782388310109323264
author Sun, Xianchang
Wu, Xingguo
Zhou, Yan
Yu, Xinyan
Zhang, Wenjuan
author_facet Sun, Xianchang
Wu, Xingguo
Zhou, Yan
Yu, Xinyan
Zhang, Wenjuan
author_sort Sun, Xianchang
collection PubMed
description BACKGROUND: The aim of this study was to determine the relevance of apelin and insulin resistance (IR) with polycystic ovary syndrome (PCOS) and to assess the possible therapeutic effect of the combined therapy of drospirenone-ethinylestradiol (DRSP-EE) combined with metformin. MATERIAL/METHODS: Sixty-three PCOS patients and 40 non-PCOS infertile patients were recruited. The fasting serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), prolactin (PRL), estradiol (E(2)), glucose (FBG), insulin (FINS), and apelin at the early follicular phase were measured. To further investigate the relation between apelin and IR, we treated the PCOS patients with DRSP-EE (1 tablet daily, 21 d/month) plus metformin (500 mg tid) for 3 months. All of the above indices were measured again after treatment. RESULTS: 1) Levels of apelin, LH, LH/FSH, T, and FINS, as well as homeostatic model assessment of IR (HOMA-IR) in PCOS patients, were significantly higher than in the control group before treatment. 2) These indices significantly decreased after treatment with DRSP-EE plus metformin. 3) Correlation analysis showed that apelin level was positively correlated with body mass index (BMI), FINS level, and HOMA-IR. CONCLUSIONS: Apelin level significantly increased in PCOS patients. The combined therapy of DRSP-EE plus metformin not only decreases IR, but also improves apelin level. This combination is a superior approach for PCOS treatment.
format Online
Article
Text
id pubmed-4556163
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher International Scientific Literature, Inc.
record_format MEDLINE/PubMed
spelling pubmed-45561632015-09-15 Evaluation of Apelin and Insulin Resistance in Patients with PCOS and Therapeutic Effect of Drospirenone-Ethinylestradiol Plus Metformin Sun, Xianchang Wu, Xingguo Zhou, Yan Yu, Xinyan Zhang, Wenjuan Med Sci Monit Clinical Research BACKGROUND: The aim of this study was to determine the relevance of apelin and insulin resistance (IR) with polycystic ovary syndrome (PCOS) and to assess the possible therapeutic effect of the combined therapy of drospirenone-ethinylestradiol (DRSP-EE) combined with metformin. MATERIAL/METHODS: Sixty-three PCOS patients and 40 non-PCOS infertile patients were recruited. The fasting serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), prolactin (PRL), estradiol (E(2)), glucose (FBG), insulin (FINS), and apelin at the early follicular phase were measured. To further investigate the relation between apelin and IR, we treated the PCOS patients with DRSP-EE (1 tablet daily, 21 d/month) plus metformin (500 mg tid) for 3 months. All of the above indices were measured again after treatment. RESULTS: 1) Levels of apelin, LH, LH/FSH, T, and FINS, as well as homeostatic model assessment of IR (HOMA-IR) in PCOS patients, were significantly higher than in the control group before treatment. 2) These indices significantly decreased after treatment with DRSP-EE plus metformin. 3) Correlation analysis showed that apelin level was positively correlated with body mass index (BMI), FINS level, and HOMA-IR. CONCLUSIONS: Apelin level significantly increased in PCOS patients. The combined therapy of DRSP-EE plus metformin not only decreases IR, but also improves apelin level. This combination is a superior approach for PCOS treatment. International Scientific Literature, Inc. 2015-08-28 /pmc/articles/PMC4556163/ /pubmed/26314870 http://dx.doi.org/10.12659/MSM.894926 Text en © Med Sci Monit, 2015 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Clinical Research
Sun, Xianchang
Wu, Xingguo
Zhou, Yan
Yu, Xinyan
Zhang, Wenjuan
Evaluation of Apelin and Insulin Resistance in Patients with PCOS and Therapeutic Effect of Drospirenone-Ethinylestradiol Plus Metformin
title Evaluation of Apelin and Insulin Resistance in Patients with PCOS and Therapeutic Effect of Drospirenone-Ethinylestradiol Plus Metformin
title_full Evaluation of Apelin and Insulin Resistance in Patients with PCOS and Therapeutic Effect of Drospirenone-Ethinylestradiol Plus Metformin
title_fullStr Evaluation of Apelin and Insulin Resistance in Patients with PCOS and Therapeutic Effect of Drospirenone-Ethinylestradiol Plus Metformin
title_full_unstemmed Evaluation of Apelin and Insulin Resistance in Patients with PCOS and Therapeutic Effect of Drospirenone-Ethinylestradiol Plus Metformin
title_short Evaluation of Apelin and Insulin Resistance in Patients with PCOS and Therapeutic Effect of Drospirenone-Ethinylestradiol Plus Metformin
title_sort evaluation of apelin and insulin resistance in patients with pcos and therapeutic effect of drospirenone-ethinylestradiol plus metformin
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556163/
https://www.ncbi.nlm.nih.gov/pubmed/26314870
http://dx.doi.org/10.12659/MSM.894926
work_keys_str_mv AT sunxianchang evaluationofapelinandinsulinresistanceinpatientswithpcosandtherapeuticeffectofdrospirenoneethinylestradiolplusmetformin
AT wuxingguo evaluationofapelinandinsulinresistanceinpatientswithpcosandtherapeuticeffectofdrospirenoneethinylestradiolplusmetformin
AT zhouyan evaluationofapelinandinsulinresistanceinpatientswithpcosandtherapeuticeffectofdrospirenoneethinylestradiolplusmetformin
AT yuxinyan evaluationofapelinandinsulinresistanceinpatientswithpcosandtherapeuticeffectofdrospirenoneethinylestradiolplusmetformin
AT zhangwenjuan evaluationofapelinandinsulinresistanceinpatientswithpcosandtherapeuticeffectofdrospirenoneethinylestradiolplusmetformin