IgM in the Kidney: A Multiple Personality Disorder

IgM in the blood of normal individuals consists mainly of “natural” polyreactive antibodies. Natural IgM are thought to provide an initial defense against infection and promote the healing of wounded cells. Yet, as Panzer and colleagues show, these benefits can be eclipsed when the IgM binds to dama...

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Detalles Bibliográficos
Autores principales: Platt, Jeffrey L., Cascalho, Marilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556166/
https://www.ncbi.nlm.nih.gov/pubmed/26323070
http://dx.doi.org/10.1038/ki.2015.153
Descripción
Sumario:IgM in the blood of normal individuals consists mainly of “natural” polyreactive antibodies. Natural IgM are thought to provide an initial defense against infection and promote the healing of wounded cells. Yet, as Panzer and colleagues show, these benefits can be eclipsed when the IgM binds to damaged cells of the glomerulus, activating complement. IgM in glomeruli thus signifies cellular damage and may warn that the pace of that damage exceeds the capacity for repair.

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